Medication (de)prescribing in hospitalized geriatric patients with sarcopenia, less is more?

Recruiting

Conditions: 10017959
10047075
stoppen/ starten/ dosisaanpassing van medicatie bij acuut zieke sarcopene geriatrische patienten met polyfarmacy en diverse uitgebreide co-morbiditeit waarbij de betrokken aandoeningen heel divers kunnen zijn en de reden van de medicatie wijziging ook verschillend kan zijn.
medication adjustment in older frail hospitalized patients with low muscle strength and muscle mass using at least 5 different medications. (de)prescribing in acutely ill hospitalized sarcopenic geriatric patients with polypharmacy.

Registration Number: NL-OMON53702

Lead Sponsor: Zuyderland Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 160

Inclusion Criteria

frail older adults, 70 Y and older with sarcopenia and polypharmacy admitted to
the acute care hospital ward because of an acute medical problem

Exclusion Criteria

If a patient is not instructable. If a patient has an implantable cardioverter
defibrillator (ICD) or no informed consent or if there is no (legal)
representative with informed consent if the patient is (temporary)
incapacitated.

Patients in a palliative phase will be excluded from this study, since most
medication will be stopped in a palliative setting.

Finally, patients with an expected admission time of less than 48 hours will be
excluded due to logistic reasons (48 hours are needed to screen for
suitability, minimum of 24 hours to consider participation).

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>number and type of medication stopped during medication review and not<br /><br>restarted within 1, 3 and 6 months</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints: number and severity of Adverse Drug Reactions (ADR) and<br /><br>complications due to medication (e.g. delirium or falls), hospital readmission,<br /><br>quality of life (QoL) and mortality</p><br>