Executive Training and Brain in School-Age Children
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Change in brain functional BOLD activity after one month of executive training as assessed by MRI in regions subtending executive functioning.
研究概览
简要总结
The purpose of this study is to determine whether a daily executive training to cognitive inhibition, working memory or mindfulness as compared to an active control condition has a near- and far-transfer impact on brain and behavioral measures as collected in children aged 9-10 years, either born preterm or full-term.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 9 Years 至 10 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Change in brain functional BOLD activity after one month of executive training as assessed by MRI in regions subtending executive functioning.
时间窗: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
Change in brain activation will be measured with functional magnetic resonance imaging (fMRI) during two different tasks: a Stop Signal task assessing inhibition and a Dot task assessing working memory.
Change in cognitive behavioral measures after one month of executive training as assessed by cognitive testing
时间窗: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
The cognitive testing session includes several tasks assessing executive functioning under different conditions. Will be investigated: 3.a. Response Time 3.b. Accuracy
Change in brain cortical structure after one month of executive training as assessed by anatomical MRI in regions subtending executive functioning.
时间窗: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
Change in brain cortical structure will be measured with anatomical magnetic resonance imaging (aMRI) using four different measures: 2.a. grey matter volume 2.b. cortical thickness 2.c. cortical surface area 2.d. curvature
次要结局
- Genetic variations measured by Single Nucleotide Polymorphism (SNP) genotyping(Pretest (t0))
- Sulcal morphometry measured by anatomical MRI(Pretest (t0))