Executive Training and Brain in School-Age Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy Children
- Sponsor
- University Hospital, Caen
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Change in brain functional BOLD activity after one month of executive training as assessed by MRI in regions subtending executive functioning.
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to determine whether a daily executive training to cognitive inhibition, working memory or mindfulness as compared to an active control condition has a near- and far-transfer impact on brain and behavioral measures as collected in children aged 9-10 years, either born preterm or full-term.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change in brain functional BOLD activity after one month of executive training as assessed by MRI in regions subtending executive functioning.
Time Frame: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
Change in brain activation will be measured with functional magnetic resonance imaging (fMRI) during two different tasks: a Stop Signal task assessing inhibition and a Dot task assessing working memory.
Change in cognitive behavioral measures after one month of executive training as assessed by cognitive testing
Time Frame: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
The cognitive testing session includes several tasks assessing executive functioning under different conditions. Will be investigated: 3.a. Response Time 3.b. Accuracy
Change in brain cortical structure after one month of executive training as assessed by anatomical MRI in regions subtending executive functioning.
Time Frame: 3 months: Pretest (t0), immediate Post-test (t0+1 month), deferred post-test (t0+3 months)
Change in brain cortical structure will be measured with anatomical magnetic resonance imaging (aMRI) using four different measures: 2.a. grey matter volume 2.b. cortical thickness 2.c. cortical surface area 2.d. curvature
Secondary Outcomes
- Genetic variations measured by Single Nucleotide Polymorphism (SNP) genotyping(Pretest (t0))
- Sulcal morphometry measured by anatomical MRI(Pretest (t0))