Effectiveness of vaginal estriol with lactobacilli on urinary symptoms in postmenopausal women: a randomized-controlled trial

Phase 3

Completed

• Conditions: rinary tract symptoms in postmenopausal women; Lower urinary tract symptoms; Administration, Intravaginal; Estriol

• Registration Number: TCTR20210623003
• Lead Sponsor: Khon Kaen University

Brief Summary

Proportion of women who had improvement of symptom severity scores after treatment were not different between group.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-23
• Study Completion: 2021-08-30
• Results First Posted: 2023-01-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 76

Inclusion Criteria

Postmenopausal women with urinary tract symptoms (frequency or urgency or dysuria or nocturia or stress urinary incontinence or urgency urinary incontinence)

Exclusion Criteria

Previous vaginal or urethral surgery or hysterectomy, Pelvic organs prolapsed stage 3-4, History of endometrial hyperplasia or cancer, History of breast cancer, Undiagnosed AUB, Allergic reaction to vaginal tablet, History of vaginal estrogen or systemic estrogen use in previous month, History of muscarinic antagonist or beta-3 adrenergic agonist in previous month, Currently using the vaginal pessary, BMI exceeding 25 kg/m*m, Cannot understand Thai language, Deny participation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement of urinary tract symptoms at the end of the study visual analog scale

Secondary Outcome Measures

Name	Time	Method
Mean symptoms score at the end of the study Visual analog scale,Quality of life at the end of the study IIQ-7,Satisfaction at the end of the study Visual analog scale,Adverse effect at the end of the study Questionnaire