The Effect of Exercise on Cognition and Preventing Depression in Young People

Not Applicable

Completed

• Conditions: Subthreshold Depression; Exercise; Clinically-well; Cognitive Change

• Registration Number: NCT04816617
• Lead Sponsor: Guangzhou Psychiatric Hospital

Brief Summary

It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression with as high as 25%-50% within one year. The cognitive development of adolescents is a critical area of research, given its significant implications for academic performance, mental health, and overall well-being. During adolescence, the brain undergoes substantial structural and functional changes, particularly in regions associated with executive function, memory, and processing speed. These changes provide a unique opportunity to explore interventions that can support and enhance cognitive development. One such promising intervention is physical exercise. Adolescence is characterized by rapid cognitive growth, including improvements in executive functions such as planning, decision-making, and inhibitory control. These cognitive abilities are essential for academic success and social interactions. However, this period also presents risks for cognitive and emotional disturbances, making it vital to identify effective strategies to promote healthy cognitive development. Despite the promising evidence, there is a need for more rigorous research, particularly long-term randomized controlled trials (RCTs), to establish the causal relationship between exercise and cognitive function in adolescents, including those with sub-threshold depression. Most existing studies have focused on short-term interventions or specific cognitive tasks, leaving a gap in our understanding of the sustained effects of exercise over an extended period. Additionally, the transition from supervised to unsupervised exercise and its impact on adherence and cognitive outcomes is underexplored. There is also a need to evaluate the potential of exercise as a preventive strategy against the development of major depressive disorder in this vulnerable population. Additionally, evidence suggests that participants with lower baseline levels of physical activity may experience more significant cognitive improvements from exercise interventions than those with higher baseline activity levels. This highlights the importance of considering baseline physical activity levels when assessing the effectiveness of exercise on cognitive outcomes.

This study will particularly focus on the cognitive domains of attention, memory, and processing speed. These domains are critical for academic success and daily functioning and are often impacted in adolescents with sub-threshold depression. Previous research has shown that these domains are particularly responsive to physical exercise interventions.

Detailed Description

This is multi-center, psycho-education randomized controlled trial, consisting of two periods with each of 6 months (i.e supervised and maintenance period). In the exercise intervention arm, during the first 6 months, participants will be asked to do moderate-intensity aerobic exercise 3-4 times a week, which will be supervised in person by physical educators/professionals. In the next 6-month maintenance period, participants will be asked to continue doing aerobic exercise at the same intensity and frequency, which will not be supervised in person by educators/professionals, but they will be sent reminders and report adherence monthly. All of the physical activity will be recorded by accelerometer at scheduled time points (e.g. the first week, 6 week, 3 month, 6 month, 9 month, 12 month). Psycho-education group will be given 6 sections of general psycho-education onsite and/or virtually dependent on the surroundings with regards to the impact of the COVID-19 pandemic. The main aim of this trial is to investigate the effect of long-term aerobic exercise on cognition and prevention depression in young people with or without subthreshold depression.

Study Timeline

• Study First Submitted: 2021-03-23
• Study First Submitted QC: 2021-03-23
• Study First Posted: 2021-03-25
• Study Start: 2021-10-21
• Primary Completion: 2023-03-31
• Study Completion: 2023-03-31
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-24
• Last Update Posted: 2024-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 628

Inclusion Criteria

• PHQ-9 ≥5
• 12~17 years old.

Exclusion Criteria

• Current or past DSM-5 criteria for major depressive disorder,Bipolar disorder, Schizophrenia.
• Musculoskeletal problems such as arthritis, gout, osteoporosis, or back, hip or knee pain that may interfere with exercising
• A history of organic brain disease or brain trauma
• Alcohol, drug or other psychoactive substance abuse or dependence
• Currently enrolled in another exercise study
• Any conditions that would make exercise unsafe or unwise
• Taking medication that interferes with heart rate response to exercise such as beta blockers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Changes from baseline in Attention measure by Choice Reaction Time task (CRT) incorporated into THINC-it®	month 12	Attention will be measured by the Choice Reaction Time task (CRT).

Secondary Outcome Measures

Name	Time	Method
Physical activity level	Month 6 and 12	The International Physical Activity Questionnaire - Short Form (IPAQ - SF) will be used to assess physical activity level
P Wave changes over time	Month 6 and 12	Brain activity will be detected by Electroencephalograph (EEG)
Changes from baseline in memory measured N-back memory task (N-BACK)	month 6 and month 12	N-back memory task (N-BACK) was used to measure short-term memory.
Changes from baseline in Processing Speed.	Month 6 and 12	Digit Symbol Substitution Test (DSST) was used to measure Processing Speed.
Changes from baseline in executive function.	Month 6 and 12	Trail Making Test-B (TMT-B) was used to measure Executive function.
Changes from baseline in Attention measure by Choice Reaction Time task (CRT)	month 6	Attention measure by Choice Reaction Time task (CRT)
The rate of occurrence of MDD	Month 6 and month 12	Kiddie-Sads-Present and Lifetime Version (K-SADS-PL)
Changes from baseline in subjective cognition measured by Perceived Deficits Questionnaire 5 (PDQ-5)	Month 6 and 12	Perceived Deficits Questionnaire 5 (PDQ-5) is a subjective measure, which broadly evaluates attention/concentration, planning/organisation, as well as retrospective and prospective memory.
Occurrence of Non-suicidal self-injury and suicidal behavior	Month 6 and month 12
New onset of subthreshold depression in healthy volunteers	Month 6 and 12	subthreshold depression is defined by DSM-5 Other specified Depressive Disorder and Unspecified Depressive Disorder
Levels of inflammatory biomarkers from baseline	Month 6 and month 12	inflammatory biomarkers (IL-6, CRP etc) will be analyzed using ELISA

Trial Locations

Locations (1)

The first Huaiji middle school; 🇨🇳 Shaoxing, Guangdong, China