Role of ward-based goal-directed fluid therapy (GDFT) in acute pancreatitis: a feasibility randomised controlled trial

Royal Free London NHS Foundation Trust0 个研究点目标入组 50 人开始时间: 2018年4月9日最近更新: 2024年5月21日

适应症

试验速览

2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/31601585 protocol (added 14/10/2019) 2022 Results article in https://doi.org/10.1016/j.ijsu.2022.106737 (added 12/07/2022) 2023 Other publications in https://doi.org/10.1186/s13063-023-07191-6 Reflections (added 10/05/2024)

•Acute pancreatitis will be confirmed by international consensus criteria for diagnosis of acute pancreatitis i.e. two of the following three features:
•1. Abdominal pain consistent with acute pancreatitis (acute onset of a persistent, severe, epigastric pain often radiating to the back)
•2. Serum amylase or lipase activity at least three times greater than the upper limit of normal
•3. Characteristic findings of acute pancreatitis on contrast-enhanced computed tomography (CECT) and less commonly magnetic resonance imaging (MRI) or transabdominal ultrasonography

•1. Patients transferred for the management of complications of acute pancreatitis
•2. Patients requiring immediate admission to the Intensive Therapy Unit (ITU)
•3. Chronic pancreatitis in whom an acute exacerbation cannot be confirmed
•4. Current or past cardiac failure
•5. Unable to provide fully informed consent

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