Ward-based goal-directed fluid therapy (GDFT) in acute pancreatitis
- Conditions
- Acute pancreatitisDigestive System
- Registration Number
- ISRCTN36077283
- Lead Sponsor
- Royal Free London NHS Foundation Trust
- Brief Summary
2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/31601585 protocol (added 14/10/2019) 2022 Results article in https://doi.org/10.1016/j.ijsu.2022.106737 (added 12/07/2022) 2023 Other publications in https://doi.org/10.1186/s13063-023-07191-6 Reflections (added 10/05/2024)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
Acute pancreatitis will be confirmed by international consensus criteria for diagnosis of acute pancreatitis i.e. two of the following three features:
1. Abdominal pain consistent with acute pancreatitis (acute onset of a persistent, severe, epigastric pain often radiating to the back)
2. Serum amylase or lipase activity at least three times greater than the upper limit of normal
3. Characteristic findings of acute pancreatitis on contrast-enhanced computed tomography (CECT) and less commonly magnetic resonance imaging (MRI) or transabdominal ultrasonography
1. Patients transferred for the management of complications of acute pancreatitis
2. Patients requiring immediate admission to the Intensive Therapy Unit (ITU)
3. Chronic pancreatitis in whom an acute exacerbation cannot be confirmed
4. Current or past cardiac failure
5. Unable to provide fully informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method