Glycemic Response of Co-ingesting Carbohydrate and Amino Acids
- Conditions
- Metabolic Diseases
- Interventions
- Other: Rice and Amino Acid mixtures
- Registration Number
- NCT02455765
- Lead Sponsor
- Clinical Nutrition Research Centre, Singapore
- Brief Summary
The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).
- Detailed Description
Healthy male subjects will be served with amino acid mixtures in combinations of two doses and three time points along with white rice as control. The combinations were either low or high levels of amino acid mixtures. This was consumed together or 15 min, 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of treatment meal until 60 min after the consumption of white rice. Subsequent blood sample were taken at 30 min interval until 210min. The glucose and insulin in the blood will be analysed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 23
- Male
- Chinese ethnicity
- Age between 21-50 years
- Body mass index (BMI) between 18-24.9 kg/m2
- Waist circumference ≤ 90 cm for men
- Normal blood pressure (<120/80 mmHg)
- Fasting blood glucose < 6 mmol/L
- dislike the consumption of Essence of Chicken
- participating in competitive sports
- allergic to amino acids and rice
- metabolic diseases (such as diabetes, hypertension and the metabolic syndromes)
- Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency
- on prescription medication
- smokers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description pre-load low dose 30 min Rice and Amino Acid mixtures Subjects will receive 68 ml of amino acid mixture 30 min before consumption of white rice White rice control Rice and Amino Acid mixtures Subjects will consume white rice as control (50g carbohydrate) co-ingest low dose of amino acid Rice and Amino Acid mixtures Subjects will receive 68 ml of amino acid mixture together with white rice co-ingest high dose of amino acid Rice and Amino Acid mixtures Subjects will receive 136 ml of amino acid mixture together with white rice pre-load low dose15 min Rice and Amino Acid mixtures Subjects will receive 68 ml of amino acid mixture 15 min before consumption of white rice pre-load high dose 30 min Rice and Amino Acid mixtures Subjects will receive 136 ml of amino acid mixture 30 min before consumption of white rice pre-load high dose 15 min Rice and Amino Acid mixtures Subjects will receive 136 ml of amino acid mixture 15 min before consumption of white rice
- Primary Outcome Measures
Name Time Method Insulinemic response 210 minutes post consumption of carbohydrate Plasma insulin will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min
Glycemic response 210 minutes post consumption of carbohydrate Blood glucose will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min
- Secondary Outcome Measures
Name Time Method