Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients

Phase 2

• Conditions: Salivary pH; Patient Satisfaction to Taste; Antimicrobial Effect; High Caries Risk Patients
• Interventions: Drug: Chlorhexidine; Drug: Guava leaves extract

• Registration Number: NCT03773094
• Lead Sponsor: Cairo University

Brief Summary

This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients.

Also salivary pH and patient satisfaction to taste will also be tested.

Detailed Description

This study is conducted to evaluate the effect of Guava leaves extract mouth wash on anti-bacterial activity against streptococcus mutans, salivary pH and patient satisfaction to taste compared to Chlorhexidine mouth wash.

P: Population with high caries risk patients I: Intervention by Guava leaves extract mouthwash C: Control is Chlorhexidine mouthwash O1: The primary outcome is antibacterial activity. O2: The secondary outcome is salivary pH O3: The tertiary outcome is patient satisfaction to taste

Study Timeline

• Status Verified: 2018-12
• Study First Submitted: 2018-12-08
• Study First Submitted QC: 2018-12-11
• Last Update Submitted: 2018-12-11
• Study First Posted: 2018-12-12
• Last Update Posted: 2018-12-12
• Study Start: 2019-01
• Primary Completion: 2019-11
• Study Completion: 2020-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Chlorhexidine	Chlorhexidine	chemical agent Chlorhexidine as a mouthwash
Guava leaves extract	Guava leaves extract	A natural product that is prepared as a mouthwash

Primary Outcome Measures

Name	Time	Method
Anti-bacterial effect against streptococcus mutans	3 months	Antimicrobial effect against streptococcus mutans: saliva samples collected and total bacterial count measured after agar plates incubating, expressed in colony forming units

Secondary Outcome Measures

Name	Time	Method
Salivary pH	3 months	Saliva samples pH will be measured using digital pH meter to evaluate its efficacy in preventing the action of acidogenic bacteria in high caries risk patients.; It displays numerical value.