Efficacy of Dexmedetomidine given through epidural space in improving oxygenation and shunt fraction in patients undergoing lung surgery via chest wall thoracotomy.
Phase 4
Completed
- Conditions
- Health Condition 1: J00-J99- Diseases of the respiratory systemHealth Condition 2: null- Patients undergoing thoracotomy and one lung ventilation
- Registration Number
- CTRI/2014/11/005182
- Lead Sponsor
- izams institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
18-60 yrs, ASA I-II patients undergoing Thoracotomy and one lung ventilation for lung surgery.
Exclusion Criteria
Contraindication to Epidural anaesthesia, Known allergy to study drugs, Documented severe cardiovascular disease, H/o Myocardial infarction, arrhythmias, Hypertensives on treatment with alpha2 agonists, Severe neuropsychiatric disease, renal dysfunction(S.cr >1.5gm/dl), Hepatic dysfunction, Long term alcohol or other drug addiction.
Intraoperative exclusion criteria- If Spo2 decreased to < 92% at any point of time, Requirement of PEEP for maintaining oxygenation, Improper lung isolation, Significant bleed ( Hb < 8 despite transfusion), Failed Epidural, Haemodynamic fluctuations requiring use of Vasoactive drug.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Oxygenation(PaO2) and shunt fraction(Qs/Qt)Timepoint: 15 minutes after two lung ventilation (TLV15) <br/ ><br>15 and 45 minutes after one lung ventilation (OLV15, OLV45) <br/ ><br>Reinstitution of TLV (ReTLV)
- Secondary Outcome Measures
Name Time Method 1.Induction dose of Propofol, <br/ ><br>2.Heart rate, systolic, diastolic,Mean arterial pressure, Central venous pressure, Entropy values and End tidal sevoflurane concentrationTimepoint: 1.At induction <br/ ><br>2. 1,2,5 minutes after intubation, TLV15, OLV15, OLV45, Re TLV