A Comparative Study Of Nefopam-Dexamethasone And Pethidine-Dexamethasone For Post Caesarean Section Pain Management

Not Applicable

• Conditions: Anaesthesia; Post Cesearean setion pain

• Registration Number: PACTR202309805784870
• Lead Sponsor: Self

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-09-04
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 144

Inclusion Criteria

? All ASA II and III patients at term gestation for elective Caesarean section under subarachnoid block. ASA II and III are contradictions to what are labelled as exclusion criteria (PUD, DM and uncontrolled hypertension) .

Exclusion Criteria

? Patient’s refusal to give written informed consent.
? Patients with known allergy or sensitivity to the study medication
? Present or past history of peptic ulcer disease
? Contraindications to spinal anaesthesia
? Diabetes mellitus Type 1 or 2
? Systemic infection,
?Patients with coexisting hepatic, renal, or cardiovascular disease.
?History of chronic pain.
?Opioid use 48hours preceding surgery.
?Antenatal diagnosis of foetal abnormality
?Known IV drug users.
?Glaucoma
?Liver cirrhosis
?Psychiatric illnesses
?Patients on antiviral medications or live vaccines
?Uncontrolled hypertension
?Requiring more than 100mg IV Tramadol for treatment of breakthrough pain

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome for the study was the proportion of patients scoring less than or equal to 3 using the NRS, at 6 and 12 hours after the administration of study drugs

Secondary Outcome Measures

Name	Time	Method
a)Time to first analgesic request. The time from administration of study drugs to first analgesic request.<br>b)Comparison of pain scores between the two groups in the first 24 hours postoperatively.<br>c)Comparison of the Total analgesic consumption between the two groups in the first 24 hours postoperatively<br>d)Comparison of Incidences of side effects related to study drugs such as nausea and vomiting and sedation<br>