Intracardiac Flow Remodeling in Athletes

Completed

• Conditions: Cardiac Remodeling, Ventricular
• Interventions: Other: electrocardiogram and echocardiography

• Registration Number: NCT03076788
• Lead Sponsor: University Hospital, Caen

Brief Summary

The uncertainty concerning the onset and the extent of cardiac remodeling in response to intensive training hinders medical evaluation by physician. A better knowledge of the physiology of cardiac adaptation to training will enable physicians to correctly determine whether observed patterns of cardiac remodeling are physiological or pathological. This prospective study proposes to assess in a trained-athlete population the cardiac remodeling in response to intensive exercise training. This study is observational, we do not interfere with athlete's training.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-01
• Study First Submitted: 2017-02-16
• Study First Submitted QC: 2017-03-06
• Study First Posted: 2017-03-10
• Primary Completion: 2019-01-01
• Study Completion: 2019-01-01
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-11
• Last Update Posted: 2024-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Age > 18yrs old
• Ability to give written consent for participating in the study

Exclusion Criteria

• Age < 18yrs old
• Cardiac diseases, arterial hypertension, cardiac devices, diabetes, renal, liver or pulmonary failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sedentary controls	electrocardiogram and echocardiography	Sedentary patients assessed in the cardiology unit with a normal heart function. The medical examination consists in a clinical exam, an electrocardiogram and an echocardiography.
Athletes	electrocardiogram and echocardiography	Professional and amateur athletes examined during the medical follow-up at the medical sport centre of Caen University Hospital. The medical examination consists in a clinical exam, an electrocardiogram and an echocardiography.

Primary Outcome Measures

Name	Time	Method
Evaluation of ventricular response to exercise training by echocardiography.	Day 1	1. 2D- morphological and functional parameters of both left and right ventricles: * end-diastolic and end-systolic dimensions (cm); * left ventricular mass (g); * ventricular end-diastolic and end-systolic areas (cm²); * ventricular ejection fraction (%); * atrial volumes (ml); * diastolic indices by pulsed wave Doppler and tissue Doppler (cm/s); * myocardial deformation by speckle tracking (%); 2. 3D- morphological and functional parameters of both left and right ventricles: * ventricular full volumes (ml); * ejection fraction (%); 3. Intracardiac flow measurements by color Doppler M-mode: estimation of intra ventricular pressure gradients between the base and the apex (mmHg).

Secondary Outcome Measures

Name	Time	Method
Evaluation of ventricular response to exercise training by electrocardiogram	Day 1	* heart rate (bpm),; * ventricular hypertrophy (mV); * atrial remodeling (mV)
Sport and medical history questionnaire	Day 1	exercise training program, medical past history, cardiovascular risk factors, treatments, doping.

Trial Locations

Locations (1)

CHU de CAEN; 🇫🇷 Caen, Normandie, France