Myocardial Mechanics in Athlete's Heart
- Conditions
- Athlete Heart
- Interventions
- Other: EchocardiographyOther: Cardiopulmonary exercise testing
- Registration Number
- NCT05543525
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling. The lower range of normal values of lLeft ventricle systolic ejection fraction (LVEF) and global longitudinal strain (GLS) in athletes makes it difficult to differentiate changes related to adaptive remodelling or indicative of early cardiomyopathy.
This study aims to improve the assessment of athletes' hearts by identifying echocardiographic phenotypes, using a speckle tracking including temporal deformation pattern and layer-specific approach, and to define predictive factors of subtle LV systolic dysfunction and of mechanical LV abnormalities.
- Detailed Description
Healthy male athletes belonging to local clubs, who underwent a pre-participation medical evaluation at the University Hospital of Nancy between 2013 and 2020, will be screened. Clinical, echocardiographic and cardiopulmonary exercise testing data will be compared to a group of healthy men from the STANISLAS cohort. Subtle LV dysfunction will be defined by a GLS \<17.5%.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 191
- athletes who underwent a pre-participation medical evaluation in the Nancy University Hospital between January 1st, 2013, and January 1st, 2020
- female athletes,
- athletes followed for cardiomyopathy
- athletes who did not have transthoracic echocardiography (TTE) performed.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Male Athletes Echocardiography Athletes who underwent a pre-participation medical evaluation in the Nancy University Hospital between January 1st, 2013, and January 1st, 2020. Male Athletes Cardiopulmonary exercise testing Athletes who underwent a pre-participation medical evaluation in the Nancy University Hospital between January 1st, 2013, and January 1st, 2020. Control Group Echocardiography A subgroup of 161 participants in a population-based cohort (STANISLAS Cohort) restricted by age and sex to create a control group in the current analysis. Control Group Cardiopulmonary exercise testing A subgroup of 161 participants in a population-based cohort (STANISLAS Cohort) restricted by age and sex to create a control group in the current analysis.
- Primary Outcome Measures
Name Time Method Multilayer (= epi- and endocardial) left ventricular global longitudinal strain using Speckle-tracking echocardiography Baseline expressed in %
- Secondary Outcome Measures
Name Time Method BMI baseline kg/m²
PST (postsystolic thickening) assessed by Speckle-tracking echocardiography baseline expressed in %
Height baseline meter
Weight baseline meter
Age Baseline years
Heart rate baseline bpm
Type of practiced sport baseline soccer, basketball, handball
Inter ventricular septum diameter baseline mm
Left ventricle indexed mass baseline g/m²
Cardiac Index baseline ml/min/m²
Maximal E-wave velocity and Maximal A-wave velocity baseline m/s
Left atrium End-systolic volume baseline ml/m²
Left ventricular Ejection Fraction baseline using simpson's biplane method, expressed in %
left ventricular End-diastolic volume baseline ml
left ventricular global longitudinal strain (peak G) assessed by Speckle-tracking echocardiography baseline expressed in %
PSI (pre stretch index) assessed by Speckle-tracking echocardiography baseline expressed in %
Peak VO2 baseline L/min
Trial Locations
- Locations (1)
Chru Nancy
🇫🇷Nancy, France