Serum Levels of Vitamin D and IL8 in Patients With Periodontitis: A Case-control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- Serum Levels of 25(OH)vitamin D
研究概览
简要总结
We evaluated vitamin D and IL8 levels in the serum of patients with periodontitis as well as the healthy controls to correlate their levels with the degree of periodontitis.
详细描述
The primary objective of this study is to assess the levels of vitamin D and IL8 in the serum of individuals diagnosed with periodontitis and compare them with those of a healthy control group. The study also aims to establish correlations between these serum levels and the degree of periodontitis severity.
Two groups will be recruited: patients diagnosed with periodontitis and a control group consisting of individuals without periodontal disease.
The participants will be matched for age, gender, and other relevant demographic factors to minimize confounding variables.
Serum samples will be collected from both groups. Periodontitis severity will be determined using established clinical indices, such as probing depth, clinical attachment loss, and bleeding on probing.
Vitamin D levels in the serum will be measured using standardized laboratory techniques.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •presence of at least twenty teeth.
- •Periodontitis patients with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2 mm and probing depth (PD)≥4 mm.
- •presence of ≥40% sites with bleeding on probing.
- •Healthy individuals matched for age and gender, who presented no systemic disease, no drugs were taken, no sites with PD ≥4 mm or CAL ≥4 mm, or radiographic signs of bone loss were enrolled, such as a control group.
- •Exclusion criteria
- •Intake of contraceptives, immunosuppressive, antibiotics or anti-inflammatory drugs throughout the last three months prior to the study.
- •Pregnant and lactating females.
- •Diabetic patients.
- •History of medications that might affect bone and mineral metabolism and/or periodontal health.
- •Taking multivitamins and food supplement which contain vitamin D.
- •Malabsorption syndrome or patient with chronic diarrhea.
- •Treatment with bisphosphonates in the past 12 months or lifetime exposure to bisphosphonates for more than 3 years.
排除标准
- 未提供
结局指标
主要结局
Serum Levels of 25(OH)vitamin D
时间窗: Laboratory evaluation after samples collection. it was performed in 1 month
Measurement of vitamin D levels (categorized as deficient, inadequate, or adequate) using a commercial ELISA kit.
Serum Levels of IL8
时间窗: Laboratory evaluation after samples collection. it was performed in 1 month
Measurement of IL8 levels (expressed in pg/ml) using a commercial ELISA kit.
次要结局
- Plaque Index (Pl)(1 day (Periodontal evaluation was performed one time for every patient with withdrawal of blood sample))
- Probing Pocket Depth (PPD)(1 day (Periodontal evaluation was performed one time for every patient with withdrawal of blood sample))
- Clinical Attachment Loss (CAL)(1 day (Periodontal evaluation was performed one time for every patient with withdrawal of blood sample))
研究者
Wafaa Saleh
Assistant professor
Mansoura University