Role of lung ultrasound in diagnosing and management of respiratory distress syndrome in 34 weeks neonates

Not yet recruiting

• Conditions: Respiratory disorders in diseasesclassified elsewhere,

• Registration Number: CTRI/2022/07/044166
• Lead Sponsor: Bharati Vidyapeeth Medical College

Brief Summary

This  study is being taken up to predict the the diagnostic accuracy of neonatal lung USG score as a lone marker for evaluating the need for surfactant administration in preterm infants with respiratory distress. We hypothesize that since LUS score reflects lung aeration, it will correlate with requirement of surfactant in preterm babies with respiratory distress. In future, it can prove to be an accurate and early predictor for the need for surfactant therapy in this cohort, thus, allowing timely treatment and as low as reasonably achievable (ALARA) radiation exposure.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-31
• Last Update Posted: 2022-08-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

< 34 weeks neonates admitted to NICU within 6 hours of life with respiratory distress.

Exclusion Criteria

• 34 weeks 2.

• No respiratory distress 3.
• Admission beyond 6 hours of life to NICU.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the diagnostic accuracy of lung ultrasound score in predicting the need for first dose of surfactant therapy in preterm infants (34weeks) with respiratory distress.	6 hours
To determine the diagnostic accuracy of lung USG score in predicting the need for second dose of surfactant therapy in preterm infants(34 weeks) with respiratory distress, if indicated clinically	6 hours

Secondary Outcome Measures

Name	Time	Method
To determine the change in LUS score after six hours of surfactant therapy	six hours after surfactant first dose
To determine the distribution of LUS score with corresponding oxygen saturation to fraction oxygenation ratio (S/F)	admission
To determine the distribution of LUS score with corresponding arterial/alveolar oxygenation ratio (PaO2/PAO2)	at admission
To determine the distribution of LUS score with corresponding chest x-ray (CXR)-based classification of RDS as mild, moderate and severe RDS	admission

Trial Locations

Locations (1)

Bharati Vidyapeeth Medical College; 🇮🇳 Pune, MAHARASHTRA, India

Bharati Vidyapeeth Medical College

🇮🇳Pune, MAHARASHTRA, India

Dr Pari Singh

Principal investigator

8178646479

parisingh19@icloud.com