Early start vs. Conventional start Peritoneal Dialysis in Cardiorenal syndrome type 1

Completed

• Conditions: Cardiorenal syndrome type 1 (AKI stage 2 from acute worsening cardiac function); Cardiorenal syndrome type 1; peritoneal dialysis; AKI

• Registration Number: TCTR20200928003
• Lead Sponsor: n/a

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-09-28
• Study Completion: 2021-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Age >= 18 years old
- AKI stage 2 (KDIGO criteria) with cardiorenal syndrome type1
- Respiratory failure (on ETT and need mechanical ventilator)

Exclusion Criteria

- Secondary peritonitis
- Need emergency dialysis (K>6 mEq/L, HCO3 < 12 mmol/L, FiO2/PaO2 < 200 with pulmonary edema, physician judgement that required emergency dialysis)
- Morbid obesity (BMI > 35 kg/m2)
- CKD stage 4-5
- Active infection with sepsis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
30-day mortality 30 days after randomization death or alive

Secondary Outcome Measures

Name	Time	Method
5-day fluid balance end of day 5 after randomization ml,Major adverse kidney event at 90 days (MAKE90) 90 day death or dialysis dependence or serum creatinine persistent increase more than 2x from baseline,serum creatinine at hospital discharge, 30 and 90 days after randomization mg/dl,PD related complication During first 5 PD sessions PD catheter insertion complication, PD related infectious, PD related metabolic disturbance ,5-day sodium removal end of day 5 after randomization mmol/l of sodium from urine and PD