NCT01881386已完成不适用
Investigation of Lactate Measured Using Magnetic Resonance Spectroscopy as a Biomarker of Tumour Response
Institute of Cancer Research, United Kingdom1 个研究点 分布在 1 个国家目标入组 37 人开始时间: 2013年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 1
- 主要终点
- Correlation between changes in MRS lactate measurements at two time points after treatment and clinical response
研究概览
简要总结
This project is designed to investigate whether measurements of lactate in tumours, made using a magnetic resonance technique similar to MRI, is an effective non-invasive method to detect whether some new targeted drugs are having their desired effect.
The study hypothesis is that by using magnetic resonance spectroscopy techniques, we will be able to observe changes in tumour lactate levels in vivo, in response to treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cohort 1:lymphoma patients
- •minimum lesion size of 2cm
- •not pretreated but scheduled to be treated with CHOP (Cyclophosphamide, Hydroxydaunomycin,Oncovin and Prednisolone)
- •Cohort 2:Colorectal patients
- •metastatic disease of at least 2cm
- •not pretreated
- •Cohort 3:Phase 1 Drug Development
- •minimum lesion size at least 2cm
- •Cohort 4: Brain
- •primary brain tumours receiving radiotherapy and temozolomide
- •cerebral lymphoma receiving standard chemotherapy
排除标准
- •MRI incompatible metal implants
- •Claustrophobia
- •Inability to tolerate a 40 minute MRI scan
结局指标
主要结局
Correlation between changes in MRS lactate measurements at two time points after treatment and clinical response
时间窗: 7 and 21 days post treatment
次要结局
- Reproducibility of MRS lactate measurement(Two baseline measurements taken at day -7 to 0 pre-treatment)
研究者
Nandita deSouza
Professor of Translational Imaging
Institute of Cancer Research, United Kingdom
研究点 (1)
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