Comparison of blood levels of factors involved in resolving inflammation in individuals with features of the metabolic syndrome versus matched healthy controls

Not Applicable

Completed

• Conditions: Overweight men and women; Cardiovascular - Other cardiovascular diseases; Diet and Nutrition - Obesity

• Registration Number: ACTRN12610000708055
• Lead Sponsor: Professor Trevor Mori

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-08-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Men and post-menopausal women not taking hormone replacement therapy, aged 20-70 years, will be recruited from the general population by newspaper advertisements. Subjects will recruited on the basis of being untreated but having features of the metabolic syndrome using the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP: ATP III). They will be invited to participate if they have a waist circumference >102cm for males and >88cm for females and systolic blood pressure (SBP) >130 mmHg,
Age and gender matched healthy control subjects will be recruited from the general population. Subjects will be included if in the age range 20 to 70 years with a waist circumference <102cm for males and <88cm for females and no other defining criteria for the metabolic syndrome.

Exclusion Criteria

Smokers, history of cardiovascular or peripheral vascular disease, diabetes, renal disease, liver disease or taking anti-hypertensive agents, lipid lowering drugs, aspirin or non-steroidal anti-inflammatory drugs, omega-3 fatty acids or >2 fish meals /week.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma and serum anti-inflammatory resolvins and protectins[Blood samples will be taken at week 0 and at weeks 3 and 4.]

Secondary Outcome Measures

Name	Time	Method
Other anti-inflammatory metabolites are Interleukin-6 (IL-6) and C-Reactive Protein (CRP)[Blood samples will be taken at week 0 and at weeks 3 and 4.]