Study of Blood and Tumor Samples From Men With an Inherited Risk of Prostate Cancer
- Conditions
- Prostate Cancer
- Registration Number
- NCT00959023
- Lead Sponsor
- Institute of Cancer Research, United Kingdom
- Brief Summary
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify genes related to cancer.
PURPOSE: This clinical trial is studying blood and tumor samples from men with an inherited risk of prostate cancer.
- Detailed Description
OBJECTIVES:
* To find genes that predispose to prostate cancer (using genetic linkage and other molecular biology techniques).
* To determine if genes that predispose to prostate cancer are associated with disease and treatment parameters.
* To determine if genes that predispose to prostate cancer are associated with environmental factors.
* To estimate the percentage of prostate cancer patients who have a positive family history of the disease.
* To estimate the relative risk of developing prostate cancer in a currently unaffected member of a prostate cancer family.
* To ascertain whether relatives of prostate cancer patients are at increased risk of developing cancers other than prostate cancer.
* To build up a large blood and tumor (both fresh and preserved) bank from patients with prostate cancer to identify prostate cancer predisposition gene(s), determine the prevalence and penetrance of prostate cancer predisposition genes in prostate cancer patients, correlate changes in prostate cancer predisposition gene(s) with disease and treatment parameters by matching with clinical data from clinical databases already held as part of the medical record on these patients, and correlate changes in prostate cancer predisposition gene(s) with environmental factors collected by questionnaire from these patients.
* To use the blood and tumor bank for marker studies (DNA, RNA, serum, plasma, protein, and other molecules) to define the role of these markers in disease prediction and progression.
* To develop microarrays from prostate cancers to determine their genetic profile and correlate this with prostate cancer genetic predisposition genes.
* To collect tissue from other unaffected and affected members of the family in cases where a genetic alteration is found, in order to ascertain whether this alteration is associated with disease risk.
* To collect tissue samples from unaffected family members who show an interest in taking part in the study.
OUTLINE: Patients are assessed by a family history and epidemiology questionnaire and undergo a medical record review.
Patients and relatives with prostate cancer may undergo blood sample collection for genetic analysis of prostate cancer predisposition genes and measurement of markers of associations with genetic changes associated with prostate cancer. Blood and tumor samples are stored for future studies.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 21000
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prostate cancer (PC) predisposition (PCP) genes
- Secondary Outcome Measures
Name Time Method Family history of PC Association of PCP genes with disease and treatment parameters Association of PCP with environmental factors Relative risk of developing PC Increased risk relatives of PC patients are to develop cancers other than PC Markers of PC that are associated with PCP genes Specific tumor genetic profile correlated with PCP genes
Trial Locations
- Locations (135)
North Devon District Hospital
🇬🇧Barnstaple, England, United Kingdom
Stoke Mandeville Hospital
🇬🇧Aylesbury-Buckinghamshire, England, United Kingdom
Basildon University Hospital
🇬🇧Basildon, England, United Kingdom
Royal United Hospital
🇬🇧Bath, England, United Kingdom
Mid Cheshire Hospitals Trust- Leighton Hopsital
🇬🇧Crewe, England, United Kingdom
Countess of Chester Hospital
🇬🇧Chester, England, United Kingdom
Colchester General Hospital
🇬🇧Colchester, England, United Kingdom
Leicester Royal Infirmary
🇬🇧Leicester, England, United Kingdom
Royal Lancaster Infirmary
🇬🇧Lancaster, England, United Kingdom
Grantham and District Hospital
🇬🇧Grantham, Lincolnshire, England, United Kingdom
Diana Princess of Wales Hospital
🇬🇧Grimsby, England, United Kingdom
Wycombe General Hospital
🇬🇧High Wycombe, England, United Kingdom
Clatterbridge Centre for Oncology
🇬🇧Merseyside, England, United Kingdom
Rosemere Cancer Centre at Royal Preston Hospital
🇬🇧Preston, England, United Kingdom
Churchill Hospital
🇬🇧Oxford, England, United Kingdom
Milton Keynes General Hospital
🇬🇧Milton Keynes, England, United Kingdom
Newcastle Upon Tyne Hospitals NHS Trust
🇬🇧Newcastle-Upon-Tyne, England, United Kingdom
Mount Vernon Cancer Centre at Mount Vernon Hospital
🇬🇧Northwood, England, United Kingdom
Stirling Royal Infirmary
🇬🇧Stirling, England, United Kingdom
Scunthorpe General Hospital
🇬🇧Scunthorpe, England, United Kingdom
Staffordshire General Hospital
🇬🇧Stafford, England, United Kingdom
Kingston Hospital
🇬🇧Surrey, England, United Kingdom
Great Western Hospital
🇬🇧Swindon, England, United Kingdom
Taunton and Somerset Hospital
🇬🇧Taunton, England, United Kingdom
East Surrey Hospital
🇬🇧Surrey, England, United Kingdom
Warwick Hospital
🇬🇧Warwick, England, United Kingdom
Sandwell General Hospital
🇬🇧West Bromwich, England, United Kingdom
Queen Victoria Hospital
🇬🇧Morecambe, United Kingdom
Singleton Hospital
🇬🇧Swansea, Wales, United Kingdom
Western Infirmary
🇬🇧Glasgow, Scotland, United Kingdom
Princess of Wales Hospital
🇬🇧Bridgend, Wales, United Kingdom
Glan Clwyd Hospital
🇬🇧Rhyl, Denbighshire, Wales, United Kingdom
Princess Anne Hospital
🇬🇧Southampton, United Kingdom
Primrose Centre at Bedford Hospitals NHS Trust
🇬🇧Bedford, England, United Kingdom
Birmingham Heartlands Hospital
🇬🇧Birmingham, England, United Kingdom
Blackpool Victoria Hospital
🇬🇧Blackpool, England, United Kingdom
Hammersmith Hospital
🇬🇧London, England, United Kingdom
Torbay Hospital
🇬🇧Torquay, England, United Kingdom
Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust
🇬🇧Birmingham, England, United Kingdom
City Hospital - Birmingham
🇬🇧Birmingham, England, United Kingdom
Royal Bournemouth Hospital
🇬🇧Bournemouth, England, United Kingdom
Bristol Royal Infirmary
🇬🇧Bristol, England, United Kingdom
Burnley General Hospital
🇬🇧Burnley, England, United Kingdom
Queen's Hospital
🇬🇧Burton-upon-Trent, England, United Kingdom
Dorset County Hospital
🇬🇧Dorchester, England, United Kingdom
Royal Devon and Exeter Hospital
🇬🇧Exeter, England, United Kingdom
Frimley Park Hospital
🇬🇧Frimley, England, United Kingdom
Harrogate District Hospital
🇬🇧Harrogate, England, United Kingdom
Princess Royal Hospital at Hull and East Yorkshire NHS Trust
🇬🇧Hull, England, United Kingdom
Royal Albert Edward Infirmary
🇬🇧Lancanshire, England, United Kingdom
Cookridge Hospital
🇬🇧Leeds, England, United Kingdom
Leeds General Infirmary
🇬🇧Leeds, England, United Kingdom
Alexandra Healthcare NHS
🇬🇧Redditch, Worcestershire, England, United Kingdom
Derriford Hospital
🇬🇧Plymouth, England, United Kingdom
Salisbury District Hospital
🇬🇧Salisbury, England, United Kingdom
Hillingdon Hospital
🇬🇧Uxbridge, England, United Kingdom
Falkirk and District Royal Infirmary
🇬🇧Falkirk, Scotland, United Kingdom
Velindre Cancer Center at Velindre Hospital
🇬🇧Cardiff, Wales, United Kingdom
Royal Gwent Hospital
🇬🇧Newport Gwent, Wales, United Kingdom
Southlands Hospital
🇬🇧Shoreham-by-Sea, United Kingdom
Edith Cavell Hospital
🇬🇧Peterborough, United Kingdom
Dorset Cancer Centre
🇬🇧Poole Dorset, England, United Kingdom
Royal Blackburn Hospital
🇬🇧Blackburn, England, United Kingdom
Sussex Cancer Centre at Royal Sussex County Hospital
🇬🇧Brighton, England, United Kingdom
Birmingham Women's Hospital
🇬🇧Edgbaston, England, United Kingdom
Whipps Cross Hospital
🇬🇧London, England, United Kingdom
Pilgrim Hospital
🇬🇧Boston, England, United Kingdom
New Cross Hospital
🇬🇧Wolverhampton, England, United Kingdom
Craigavon Area Hospital
🇬🇧Portadown, Craigavon, Northern Ireland, United Kingdom
Royal London Hospital
🇬🇧London, England, United Kingdom
Royal Derby Hospital
🇬🇧Derby, England, United Kingdom
Eastbourne District General Hospital
🇬🇧Eastbourne, England, United Kingdom
Leicester General Hospital
🇬🇧Leicester, England, United Kingdom
Epsom General Hospital
🇬🇧Epsom, Surrey, England, United Kingdom
Royal Bolton Hospital
🇬🇧Farnworth, England, United Kingdom
Altnagelvin Area Hospital
🇬🇧Londonderry, Northern Ireland, United Kingdom
Yeovil District Hospital
🇬🇧Yeovil, England, United Kingdom
Downe Hospital
🇬🇧Downpatrick, Northern Ireland, United Kingdom
Pinderfields General Hospital
🇬🇧Wakefield, Scotland, United Kingdom
Kidderminster Hospital
🇬🇧Kidderminster Worcestershire, England, United Kingdom
Leeds Cancer Centre at St. James's University Hospital
🇬🇧Leeds, England, United Kingdom
Saint Bartholomew's Hospital
🇬🇧London, England, United Kingdom
Nottingham City Hospital
🇬🇧Nottingham, England, United Kingdom
George Eliot Hospital
🇬🇧Nuneaton, England, United Kingdom
Middlesex Hospital
🇬🇧London, England, United Kingdom
Good Hope Hospital
🇬🇧Birmingham, England, United Kingdom
St. Mary's Hospital
🇬🇧London, England, United Kingdom
Macclesfield District General Hospital
🇬🇧Macclesfield, England, United Kingdom
Christie Hospital
🇬🇧Manchester, England, United Kingdom
Broomfield Hospital
🇬🇧Broomfield, England, United Kingdom
Southmead Hospital
🇬🇧Bristol, England, United Kingdom
Addenbrooke's Hospital
🇬🇧Cambridge, England, United Kingdom
Basingstoke and North Hampshire NHS Foundation Trust
🇬🇧Basingstoke, England, United Kingdom
Frenchay Hospital
🇬🇧Bristol, England, United Kingdom
Kent and Canterbury Hospital
🇬🇧Canterbury, England, United Kingdom
St. Helier Hospital
🇬🇧Carshalton, England, United Kingdom
Walsgrave Hospital
🇬🇧Coventry, England, United Kingdom
Mayday University Hospital
🇬🇧Croydon, England, United Kingdom
Darent Valley Hospital
🇬🇧Dartford Kent, England, United Kingdom
Derbyshire Royal Infirmary
🇬🇧Derby, England, United Kingdom
Russells Hall Hospital
🇬🇧Dudley, England, United Kingdom
Ipswich Hospital
🇬🇧Ipswich, England, United Kingdom
Lincoln County Hospital
🇬🇧Lincoln, England, United Kingdom
Royal Liverpool University Hospital
🇬🇧Liverpool, England, United Kingdom
Maidstone Hospital
🇬🇧Maidstone, England, United Kingdom
James Cook University Hospital
🇬🇧Middlesbrough, England, United Kingdom
Berkshire Cancer Centre at Royal Berkshire Hospital
🇬🇧Reading, England, United Kingdom
Queens Hospital
🇬🇧Romford, England, United Kingdom
Conquest Hospital
🇬🇧Saint Leonards-on-Sea, England, United Kingdom
Hope Hospital
🇬🇧Salford, England, United Kingdom
Worthing Hospital
🇬🇧Worthing, England, United Kingdom
Cancer Care Centre at York Hospital
🇬🇧York, England, United Kingdom
Belfast City Hospital Trust Incorporating Belvoir Park Hospital
🇬🇧Belfast, Northern Ireland, United Kingdom
Norfolk and Norwich University Hospital
🇬🇧Norwich, England, United Kingdom
Kings Mill Hospital
🇬🇧Nottinghamshire, England, United Kingdom
Royal Marsden - Surrey
🇬🇧Sutton, England, United Kingdom
Peterborough Hospitals Trust
🇬🇧Peterborough, England, United Kingdom
Scarborough General Hospital
🇬🇧Scarborough, England, United Kingdom
Royal Shrewsbury Hospital
🇬🇧Shrewsbury, England, United Kingdom
Stepping Hill Hospital
🇬🇧Stockport, England, United Kingdom
Wexham Park Hospital
🇬🇧Slough, Berkshire, England, United Kingdom
Solihull Hospital
🇬🇧Solihull, England, United Kingdom
Southampton General Hospital
🇬🇧Southampton, England, United Kingdom
Southport and Formby District General Hospital
🇬🇧Southport, England, United Kingdom
Southend University Hospital NHS Foundation Trust
🇬🇧Westcliff-On-Sea, England, United Kingdom
Aberdeen Royal Infirmary
🇬🇧Aberdeen, Scotland, United Kingdom
Ayr Hospital
🇬🇧Ayr, Scotland, United Kingdom
University Hospital of Wales
🇬🇧Cardiff, Wales, United Kingdom
Tameside General Hospital
🇬🇧Ashton-Under-Lyne, England, United Kingdom
Furness General Hospital
🇬🇧Barrow in Furness, England, United Kingdom
Lister Hospital
🇬🇧Stevenage, England, United Kingdom
William Harvey Hospital
🇬🇧Ashford-Kent, England, United Kingdom
Guy's Hospital
🇬🇧London, England, United Kingdom
Castle Hill Hospital
🇬🇧Cottingham, England, United Kingdom
Charing Cross Hospital
🇬🇧London, England, United Kingdom