Effect of Eggs and Egg Components on Cognitive Performance and Appetite in School-aged Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Nutrition
- Sponsor
- Toronto Metropolitan University
- Enrollment
- 19
- Locations
- 1
- Primary Endpoint
- Change in memory from baseline
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of the present study is to determine the effects of eggs and egg components on cognitive performance and appetite in children aged 9-14 years, as well as to identify the underlying physiological mechanisms in this relationship.
Detailed Description
Children will be asked to refrain from exercising the morning of their test day and inform researchers of any illness. Following a 12-hour overnight fast, children will consume a standardized breakfast of a cereal bar, fruit cup and orange juice at home (total 330 kcal). Children will be asked to avoid consumption of any other food, with the exception of water, until arrival at the laboratory 3 hours later. At the laboratory, five treatments of: (a) 2 whole eggs, (b) 2 egg whites, (c) 2 egg yolks, (d) full fat yogurt isocaloric to the 2 whole eggs, and (e) snack skipping will be provided to children 9-14 years on separate days at least 7 days apart. Cognitive performance, subjective emotion/mood, and subjective appetite will be measured for 90-minutes following snack consumption (n=25). Cognitive performance assessments will include learning and memory, spatial memory, attention and processing speed, and executive functions. In a subgroup of individuals (n=10), glucose, insulin, incretin hormones (glucagon like peptide1(GLP1) and gastric inhibitory polypeptide (GIP)),dipeptidyl peptidase 4 (DPP4), amino acids, fatty acids, and choline will be measured for 90-minutes following snack consumption.
Investigators
Nick Bellissimo
Associate Professor
Toronto Metropolitan University
Eligibility Criteria
Inclusion Criteria
- •be between 9 and 14 years of age
- •be healthy, and have been born at term
- •healthy body weight (between the 5th and 85th BMI percentile for age and gender)
Exclusion Criteria
- •children with food sensitivities or allergies to eggs, egg-products, dairy and wheat
- •children with any diagnosed learning, emotional, or behavioral disabilities
- •children on medications that may influence cognitive performance
Outcomes
Primary Outcomes
Change in memory from baseline
Time Frame: 15, 30, 60, and 90 minutes
One of five word lists composed of 15 words will be audio-visually presented to children. The majority of the words will be one syllable, and four words in each list will be two syllables long. The list will be presented at baseline and the children will be asked to recall as many words as possible at each time-point. The list will be presented for 2.5 minutes, and children will have 2 minutes for both immediate and delayed recall.
Change in spatial working memory from baseline
Time Frame: 0, 15, 30, 60, and 90 minutes
Assessed using a spatial pattern recognition test via the Membrain application. The test consists of a series of subtests where children will be presented a picture with patterns to study, and asked to identify a picture with the same pattern from a group of four images. This test will be at each time-point and takes approximately 1 minute to complete.
Change in attention from baseline
Time Frame: 0, 15, 30, 60, and 90 minutes
The continuous performance task (CPT) will be completed via the Membrain application. During the CPT task, children will be given a sequence of two letters to identify; for example respond to the detection of the letter "X" only when it is preceded by the letter "A". This task will be at each time-point and will take 3 minutes total to complete.
Change in executive function from baseline
Time Frame: 0, 15, 30, 60, and 90 minutes
The Stroop task will be completed via the Membrain application. Children will be presented with a list of words presented in colors that match the word (congruent, the word 'red' presented in red) or colors that do not match the word (incongruent, the word 'red' presented in blue). Children will be asked to identify the color of the word, not the word itself. The task is scored for the number of correct and incorrect colors identified, as well as total time to completion. This test will be at each time-point and will take 1 minute to complete.
Secondary Outcomes
- Change from baseline dipeptidyl peptidase 4 (DPP4)(0, 15, 30, 60, and 90 minutes)
- Change from baseline glucagonlike peptide1 (GLP1)(0, 15, 30, 60, and 90 minutes)
- Change from baseline mood(0, 15, 30, 60, and 90 minutes)
- Change from baseline subjective appetite(0, 15, 30, 60, and 90 minutes)
- Change from baseline cholecystokinin (CCK)(0, 15, 30, 60, and 90 minutes)
- Change from baseline insulin(0, 15, 30, 60, and 90 minutes)
- Change from baseline glycemic response(0, 15, 30, 60, and 90 minutes)
- Change from baseline amino acids(0, 15, 30, 60, and 90 minutes)
- Change from baseline fatty acids(0, 15, 30, 60, and 90 minutes)
- Change from baseline choline(0, 15, 30, 60, and 90 minutes)