Does Increased Egg Consumption Have Cognitive and Neural Benefits in Food Insecure, At-risk Adolescents?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 4
- 主要终点
- Comparison of functional activity during Eriksen-Flanker Task
研究概览
简要总结
Quality nutrient intake is essential for proper development and well-being of children in all aspects of health, including cognitive development. Eggs are of particular interest based on potential cognitive and neurological benefits due in part to significant concentrations of choline and lutein. While overall, choline and lutein have received considerable attention in the literature in relation to cognition and brain function, most studies involving intake in young adults have had short intervention periods ranging from 90 minutes to 3 days. Food insecurity has been associated with decreased academic performance. Given that populations with food insecurity have limited resources to direct towards nutrition, identifying how a widely available, highly versatile and largely affordable source of nutrients (i.e. eggs) may have favorable impacts on cognitive function and brain function will be valuable in informing public health recommendations in this at-risk population. As such the investigators will examine whether an increased egg consumption dietary prescription can have positive effects on functional activity (i.e. fMRI) during an Eriksen-Flanker task, anatomical changes in the brain (i.e. DTI, MRI), and cognitive abilities as measured by the Stop Signal Reaction Time task, Operation Span task, Raven's Progressive Matrices and the Boston Naming Task.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 13 Years 至 19 Years(Child, Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 13-19 years.
- •Household has food security status of low or very low as designated by scoring 2-6 raw score using the U.S. Household Food Security Survey Module: Six-Item Short Form.
排除标准
- •Participants unable or unwilling to provide informed consent.
- •Participants with motor, visual or hearing impairment.
- •Participants with current severe psychiatric illnesses (e.g. psychosis, schizophrenia, bipolar disorders, depression)
- •Participants with history of psychiatric hospitalization.
- •Participants with habitual egg consumption (past 3 months) of 4 eggs per week or more
- •Unable or unwilling to consume required study meals for any reason (e.g. dietary restrictions, allergies, or aversions to any of the food items used in the study).
- •History of liver or kidney disease, cardiovascular disease, hematologic disease, metabolic disease, Epilepsy (or other seizure disorder) or malignant tumor
- •Currently taking (or have taken in the past 4 weeks) any anti-anxiolytic, anti-epileptic, or anti-depression medications
- •Currently taking (or have taken in the past 4 weeks) any proton pump inhibitor medications
- •History of any cognitive disorder, medical and/or psychological conditions and/or medications affecting cognition
- •Participants with contraindications for MRI scanning.
- •aneurism clips
- •any implanted medical devices (pacemaker, neurostimulator)
- •known pregnancy
- •shrapnel in body or any injury to eye involving metal
- •any ferrous metal in body
结局指标
主要结局
Comparison of functional activity during Eriksen-Flanker Task
时间窗: Baseline (pre-intervention) and 12 weeks (post-intervention)
Changes in regional brain activation during an fMRI scan.
Comparison of grey matter anatomical change
时间窗: Baseline (pre-intervention) and 12 weeks (post-intervention)
Grey density as measured by MRI
Comparison of white matter connectivity change
时间窗: Baseline (pre-intervention) and 12 weeks (post-intervention)
White matter connectivity as measured by diffusion tensor imaging
Comparison of Eriksen-Flanker Task performance change
时间窗: Baseline (pre-intervention) and 12 weeks (post-intervention)
Eriksen-Flanker task performance compared using the drift diffusion model
Comparison of cognitive battery performance change
时间窗: Baseline (pre-intervention) and 12 weeks (post-intervention)
Cognitive performance as measured by stop signal reaction time task
次要结局
未报告次要终点
研究者
Martin Binks
Associate Professor
Texas Tech University
