Comparison of Remifentanil With Dexmedetomidine or Midazolam in Regards of Sedation Effectivity and Postoperative Cognitive Functions in Cystoscopies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Degree of sedative efficiency
研究概览
简要总结
The aim of the study was to compare the effects of remifentanil-dexmedetomidine and remifentanil-midazolam with mini-mental state examination (MMSE) in monitored anesthesia care (MAC) patients undergoing cystoscopy.
详细描述
Forty patients undergoing cystoscopy receiving remifentanil infusion of 0.05 microgram per kg-1 min-1 were randomized into two groups: Either dexmedetomidine 1 microgram per kg -1 (GroupD) or midazolam 0.2 mg kg-1h-1 (GroupM) were administered intravenously for the first 10 minutes. Subsequently anesthesia was maintained by using the bispectral index(BIS) as a continuous infusion of dexmedetomidine 0.2-0.7 microgram per kg-1h-1 or midazolam 0.05-0.15 mgkg-1h-1. Heart rate, mean arterial pressure, MMSE, sedation and the patient's and surgeon's satisfaction were determined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with indication of cystoscopy must be able to have sedation
排除标准
- •hypersensitivity to drugs used
- •morbid obesity
- •coronary disease
- •diabetes mellitus and other endocrinologic diseases
- •pregnancy
- •psychomotor diseases
结局指标
主要结局
Degree of sedative efficiency
时间窗: During cystoscopy procedure
Bispectral Index (BIS) was used.
Degree of cognitive functions
时间窗: Postoperative 60 minutes
mini-mental state examination(MMSE) test was used.
次要结局
未报告次要终点
研究者
Ayşe Hande Arpacı
Dr. at Department of Anaesthesiology and Reanimation
Gazi University