Comparison of Remifentanil With Dexmedetomidine or Midazolam in Regards of Sedation Effectivity and Postoperative Cognitive Functions in Cystoscopies
- Conditions
- Postoperative Cognitive Functions
- Registration Number
- NCT01491009
- Lead Sponsor
- Gazi University
- Brief Summary
The aim of the study was to compare the effects of remifentanil-dexmedetomidine and remifentanil-midazolam with mini-mental state examination (MMSE) in monitored anesthesia care (MAC) patients undergoing cystoscopy.
- Detailed Description
Forty patients undergoing cystoscopy receiving remifentanil infusion of 0.05 microgram per kg-1 min-1 were randomized into two groups: Either dexmedetomidine 1 microgram per kg -1 (GroupD) or midazolam 0.2 mg kg-1h-1 (GroupM) were administered intravenously for the first 10 minutes. Subsequently anesthesia was maintained by using the bispectral index(BIS) as a continuous infusion of dexmedetomidine 0.2-0.7 microgram per kg-1h-1 or midazolam 0.05-0.15 mgkg-1h-1. Heart rate, mean arterial pressure, MMSE, sedation and the patient's and surgeon's satisfaction were determined.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- patients with indication of cystoscopy must be able to have sedation
- hypersensitivity to drugs used
- morbid obesity
- coronary disease
- diabetes mellitus and other endocrinologic diseases
- pregnancy
- psychomotor diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Degree of sedative efficiency During cystoscopy procedure Bispectral Index (BIS) was used.
Degree of cognitive functions Postoperative 60 minutes mini-mental state examination(MMSE) test was used.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gazi University Faculty of Medicine Hospital
🇹🇷Ankara, Turkey