Comparison of Remifentanil With Dexmedetomidine or Midazolam in Regards of Sedation Effectivity and Postoperative Cognitive Functions in Cystoscopies
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Cognitive Functions
- Sponsor
- Gazi University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Degree of sedative efficiency
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The aim of the study was to compare the effects of remifentanil-dexmedetomidine and remifentanil-midazolam with mini-mental state examination (MMSE) in monitored anesthesia care (MAC) patients undergoing cystoscopy.
Detailed Description
Forty patients undergoing cystoscopy receiving remifentanil infusion of 0.05 microgram per kg-1 min-1 were randomized into two groups: Either dexmedetomidine 1 microgram per kg -1 (GroupD) or midazolam 0.2 mg kg-1h-1 (GroupM) were administered intravenously for the first 10 minutes. Subsequently anesthesia was maintained by using the bispectral index(BIS) as a continuous infusion of dexmedetomidine 0.2-0.7 microgram per kg-1h-1 or midazolam 0.05-0.15 mgkg-1h-1. Heart rate, mean arterial pressure, MMSE, sedation and the patient's and surgeon's satisfaction were determined.
Investigators
Ayşe Hande Arpacı
Dr. at Department of Anaesthesiology and Reanimation
Gazi University
Eligibility Criteria
Inclusion Criteria
- •patients with indication of cystoscopy must be able to have sedation
Exclusion Criteria
- •hypersensitivity to drugs used
- •morbid obesity
- •coronary disease
- •diabetes mellitus and other endocrinologic diseases
- •pregnancy
- •psychomotor diseases
Outcomes
Primary Outcomes
Degree of sedative efficiency
Time Frame: During cystoscopy procedure
Bispectral Index (BIS) was used.
Degree of cognitive functions
Time Frame: Postoperative 60 minutes
mini-mental state examination(MMSE) test was used.