Lipoprotein (a) Levels and Major Adverse Cardiac Events in Patients with Established Atherosclerotic Cardiovascular Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- 1.Association of elevated Lp(a) in established cardiovascular disease (CVD)
研究概览
简要总结
Lipoprotein(a) hasbeen considered a cardiovascular risk factor for many years. Althoughprospective, randomized, controlled outcomes studies have not been conducted,epidemiological, genome-wide association and Mendelian randomized controlledstudy data provide supporting evidence for a role of Lp(a) in CVD .
however this trail help to understand the association of Lp(a) and major adverse cardiac events related to the elevated Lp(a) levels in atherosclerotic cardiovascular disease.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •History of a myocardial infarction (MI) ≥3 months and ≤10 years before the study visit
- •History of ischemic stroke ≥ 3 months and ≤ 10 years before the study visit.
排除标准
- •1.Patients currently enrolled in clinical studies with investigational drugs 2.Patients with proven Psychiatric illness on medications 3.Patients with chronic liver disease 4.Pregnant women 5.Terminal malignancy patients.
结局指标
主要结局
1.Association of elevated Lp(a) in established cardiovascular disease (CVD)
时间窗: 3 years
3.Identifying association of anthropometric parameters with Lp(a) levels in patients with established ASCVD
时间窗: 3 years
2.Identifying relationship between raised levels of Lp(a) and other biochemical parameters including lipid profile among the sub group population with established ASCVD
时间窗: 3 years
4.Co-relation between Lp(a) and MACE rate on 18 months follow up of patients with documented ASCVD on standard medical therapy including statins
时间窗: 3 years
次要结局
- Association of elevated Lp(a) in established cardiovascular disease (CVD)(•Co-relation between Lp(a) and MACE rate on 18 months follow up of patients with documented ASCVD on standard medical therapy including statins)