SPACING TIME INTERVALS OF FENTANYL, TO DECREASE REQUIREMENT OF PROPOFOL IN GENERAL ANAESTHESIA

Phase 4

Not yet recruiting

Conditions: Other Procedures,

Registration Number: CTRI/2023/01/049283

Lead Sponsor: SDM Medical college

Brief Summary: Propofol is a common intravenous anesthetic agent for the induction of general anesthesia.

It is one of the drugs particularly suitable for general anaesthesia on account of its rapid recovery characteristics. A major drawback of propofol would be greater degree of hypotension relative to other hypnotic agents. Decreasing the induction dose of propofol can minimize the hemodynamic changes before intubation .An opioid when administered prior to propofol reduces the requirement of propofol and improves hemodynamic stability. Fentanyl is a potent synthetic mu-receptor agonist, and is the most widely used intravenous opioid for intraoperative analgesia in most parts of the world. Fentanyl gets distributed rapidly from plasma to highly vascular tissues and 80% of the injected dose leaves plasma in 5 min.When administered prior to intravenous induction, fentanyl acts synergistically with propofol and also attenuates hemodynamic response to laryngoscopy and endotracheal intubation. This study compares the effects of varying intervals between fentanyl and propofol administration on the propofol requirement for induction of general anaesthesia.

Patients will be studied in this randomized prospective observational study.

Induction of anaesthesia will be done using Inj.Fentanyl 2mcg/kg will be administered. Group 1 :patients will be given propofol injection immediately after fentanyl injection. Group 2 :will receive propofol 3 min after fentanyl injection Group 3 :will be given propofol after 5min after fentanyl injection. Propofol will be injected slowly at the rate of 1ml/3sec till loss of verbal contact. Total dose of propofol required per kg body weight for induction will be noted. Next the vital parameters like heart rate, noninvasive systolicbloodpressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MAP) will be recorded from the baseline , every minute till the completion of induction of anaesthesia.

Vital parameters will be recorded at 0, 1 ,2, 3 , 4 and 5 minutes following intubation. The recordings will then be tabulated and analyzed using SPSS.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 150

Inclusion Criteria

1.Patients willing to participate in the study 2.Patients undergoing elective surgery under general anaesthesia with endotracheal intubation 3.ASA physical status 1 and 2 4.Patients aged 18-60 years of either sex.

Exclusion Criteria

1.patient refusal 2.BMI more than or equal 30kg/m2 3.anticipated difficult airway 4.history of allergy to drugs like propofol 5.history of alcohol/drug use 6.Respiratory,cerebrovascular, renal and cardiovascular diseases including uncontrolled hypertension 7.Receiving any drugs likely to affect requirement of propofol /hemodynamic changes.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the dose requirement of propofol in induction of general anaesthesia by delaying its injection after administration of fentanyl.	1minute, 3minutes and 5minutes

Secondary Outcome Measures

Name	Time	Method
to compare hemodynamic changes like hypotension, buckling, vocalisation	1minute 3minute and 5minutes

Trial Locations

Locations (1): SDM College of medical sciences and hospital
🇮🇳
Dharwad, KARNATAKA, India
SDM College of medical sciences and hospital
🇮🇳Dharwad, KARNATAKA, India
Dr prathvi
Principal investigator
Prathvibhat25@gmail.com