Epigenetic Mechanisms and Severe Obesity (Biological Tissue Collection)

Recruiting

• Conditions: Diabetes; Obesity; Metabolic Diseases; Non-alcoholic Fatty Liver Disease

• Registration Number: NCT02663388
• Lead Sponsor: University of Lorraine

Brief Summary

The purpose of this study was to evaluate the role of vitamin status and epigenetic mechanisms on severe obesity related-complications.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01
• Study First Submitted: 2016-01-11
• Study First Submitted QC: 2016-01-20
• Study First Posted: 2016-01-26
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-26
• Last Update Posted: 2016-10-27
• Primary Completion: 2026-01
• Study Completion: 2026-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20000

Inclusion Criteria

• indication for bariatric surgery with BMI > 35 kg/m2

Exclusion Criteria

• unable to receive clear information
• refusal to sign the consent form

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of folate mediated one-carbon metabolic pathway parameters (Folates, Vitamin B12, Methionine, Homocysteine) on severe obesity-related complications before and after bariatric surgery	10 years

Secondary Outcome Measures

Name	Time	Method
Evaluation of DNA Methylation on severe obesity-related complications before and after bariatric surgery	10 years

Trial Locations

Locations (1)

University of Lorraine, CHU Nancy; 🇫🇷 Vandoeuvre Les Nancy, France