Spot Depression Study

Completed

• Conditions: Bipolar Disorder; Depressive Disorder
• Interventions: Procedure: Online questionnaire and self-administered blood spot

• Registration Number: NCT02804867
• Lead Sponsor: University of Cambridge

Brief Summary

This study aims to identify signs of depression and bipolar disorder by measuring changes of certain molecules (biomarkers) that can be detected in dried blood spots. Our goal is to use these biomarkers to develop a diagnostic test to enable early treatment, which can lead to better patient outcomes.

Detailed Description

Bipolar disorder and major depression are serious mental health conditions that have a devastating impact on patients, their families and friends, and society. Currently, no laboratory test exists for these disorders. We are trying to develop a molecular test based on blood spots (small spots of blood obtained from patients' fingertips that have been dried on special paper). Volunteers take part by filling out the questionnaire at www.spot-depression.org. They may then be selected to provide a dried blood spot, which can be collected at home using a kit that will be mailed to their address.

Study Timeline

• Study Start: 2016-03
• Study First Submitted: 2016-06-07
• Study First Submitted QC: 2016-06-14
• Study First Posted: 2016-06-17
• Primary Completion: 2016-09
• Study Completion: 2016-09
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-19
• Last Update Posted: 2017-02-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Residing in the United Kingdom
• Over 18 years of age

Exclusion Criteria

• Pregnant or breastfeeding
• Presence of blood-borne infection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control	Online questionnaire and self-administered blood spot	-
Bipolar disorder	Online questionnaire and self-administered blood spot	-
Depression	Online questionnaire and self-administered blood spot	-

Primary Outcome Measures

Name	Time	Method
Assessment of classification accuracy of protein concentrations in dried blood spots for distinguishing between bipolar disorder and depression	Baseline (at enrollment); no follow-up
Comparison of protein concentrations in dried blood spots between patient groups and controls	Baseline (at enrollment); no follow-up

Trial Locations

Locations (1)

Jordan Ramsey; 🇬🇧 Cambridge, Cambridgeshire, United Kingdom