Assessment of the sympathetic nervous system blockade of the upper limb after a brachial plexus block in patients receiving haemodialysis

Completed

• Conditions: Renal failure; Urological and Genital Diseases; Unspecified renal failure

• Registration Number: ISRCTN82322174
• Lead Sponsor: ottingham University Hospitals NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02-12
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

1. Patients with end stage renal failure
2. Over 18 years of age, either sex
3. Written consent obtained
4. Due to undergo surgery for forearm fistula creation under a regional block

Exclusion Criteria

1. Smokers
2. Damaged skin on the arm
3. Circulatory disorders such as Raynaud's disease, systemic sclerosis, sickle cell trait or disease
4. Current use of beta blockers
5. Undergoing haemodialysis for more than 12 months

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The transient hyperaemic response ratio (THRR) will be calculated for each compression using the formula THRR = F2/F1 where F1 is the initial fall in blood flow flux following compression of the brachial artery and F2 is the hyperaemic response following its release. The mean of each set of readings will be taken and compared with the subjects' normal values using a paired t-test.<br>2. Skin temperature will be compared before and after the regional block and dialysis using a t-test<br><br>Measured at pre-regional block, immediately post-regional block onset, and 4 hours after regional block.

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures