Analysis of parasympathetic nerve dysfunction during night in overlap syndrome with obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD)
Not Applicable
- Conditions
- Overlap syndrome with obstructive sleep apnea syndrome (OSA) and chronic obstructive pulmonary disease (COPD)
- Registration Number
- JPRN-UMIN000023323
- Lead Sponsor
- Comprehensive Medical Center of Sleep Disorders, Tokyo Women's Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
Not provided
Exclusion Criteria
Central sleep apnea (CSA) predominating over OSA Periodic leg movement disorders Atrial fibrillation, artificial cardiac rhythms by pacemakers, significant ectopic beats Severe systemic diseases, including malignancy in any organ, severe heart failure, heart attack or stroke, renal failure requiring dialysis, and impaired cognitive function
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of airflow limitation by continuous PAP therapy in Overlap syndrome
- Secondary Outcome Measures
Name Time Method 1) Nighttime parasympathetic nerve activity and stability estimated by instantaneous time-frequency analysis in OSA, COPD, and Overlap syndrome 2) Improvement of nighttime parasympathetic nerve activity and stability by PAP therapy in OSA and Overlap syndrome