OPMs for epilepsy

Conditions: Epilepsy

Registration Number: NL-OMON26326

Lead Sponsor: etherlands Epilepsy Foundation (NEF)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 7

Inclusion Criteria

Patients have refractory epilepsy (not responding to treatment with anti-epileptic
drugs) and are candidates for epilepsy surgery at VUmc (adults) or UMCU (children).
- We include adults (VUmc) or children of six years of age or older (UMCU).
Adults:
- Patients have already undergone a clinical SQUID-based MEG and dEEG at VUmc
- 3 patients: confirmed focal source on dEEG of mesial temporal origin
- 1 patient: frequent seizures (~daily)
Children:
- Six years of age or older
- Patients have already undergone a clinical SQUID-based MEG with simultaneous
scalp-EEG at VUmc
- Confirmed focal source of epileptiform activity in clinical MEG or EEG

Exclusion Criteria

- Already undergone surgery for their current epilepsy
- The patients have already undergone a clinical SQUID-based MEG. Those patients
who had claustrophobic or anxiety experiences from being enclosed in the
magnetically shielded room will be excluded
- Patients with many artefacts, related to either movement (restlessness, i.e. not
seizure-related) or metal implants (not MEG compatible), on their clinical SQUIDbased
MEG

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome is a demonstration of the effectiveness of OPMs as a powerful diagnostic tool in epilepsy. The parameter we study is epileptiform activity (spikes, spike-waves). We will compare the even-rate (number of spikes/minute) and the strength (in terms of signal-to-noise ratio) between the different techniques (OPM-based MEG versus SQUID-based MEG, and scalp EEG or dEEG). OPM-based MEG will be considered more effective if the event-rate or strength is higher than for the SQUID-based MEG.

Secondary Outcome Measures

Name	Time	Method
Demonstration of the ability to successfully record MEG signals during a seizure, i.e. to be able to identify epileptiform activity in a MEG signal that is not saturated by movement-artefacts.