Wearable MEG - Using novel technology to improve surgery outcome in epilepsy patients

Completed

Conditions: epilepsy
seizure
10039911
10009720

Registration Number: NL-OMON48086

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 7

Inclusion Criteria

- Patients have refractory epilepsy and are candidates for epilepsy surgery
- We include adults (VUmc) or children of six years of age or older (UMCU).
Adults:
- Patients have already undergone a clinical SQUID-based MEG and dEEG at VUmc
- 3 patients: confirmed focal source on dEEG of mesial temporal origin
- 1 patient: frequent seizures (~daily);Children:
- Six years of age or older
- Patients have already undergone a clinical SQUID-based MEG with simultaneous scalp-EEG at VUmc
- Confirmed focal source of epileptiform activity in clinical MEG or EEG

Exclusion Criteria

- Have already undergone surgery for their current epilepsy
- The patients have already undergone a clinical SQUID-based MEG. Those patients who had claustrophobic or anxiety experiences from being enclosed in the magnetically shielded room will be excluded.
- Patients with many artefacts, related to either movement or metal implants (not MEG compatible), on their clinical SQUID-based MEG

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome is a demonstration of the effectiveness of OPMs as a powerful<br /><br>diagnostic tool in epilepsy. The parameter we study is epileptiform activity<br /><br>(spikes, spike-waves). We will compare the even-rate (number of spikes/minute)<br /><br>and the strength (in terms of signal-to-noise ratio) between the different<br /><br>techniques. </p><br>

Secondary Outcome Measures