Comparison of Individualized PEEP Application Versus Fixed PEEP Application for Lung-Protective Ventilation in Patients Undergoing On-Pump Coronary Artery Bypass Grafting Surgery

Not yet recruiting

• Conditions: Peep Titration in Lung Protective Ventilation

• Registration Number: NCT07044089
• Lead Sponsor: Kocaeli University

Brief Summary

Our Primary Objective: To compare the effects of fixed PEEP versus individualized PEEP in lung protective mechanical ventilation during on-pump open heart surgery on intraoperative oxygenation level, hemodynamics, lung compliance and airway pressures.

Our Secondary Objective: To compare the duration of extubation, respiratory complications \[development of atelectasis, need for noninvasive mechanical ventilation (high-flow nasal cannula or CPAP application), need for re-intubation\], length of stay in the ICU and time to discharge in the postoperative period.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-05
• Study First Submitted: 2025-06-23
• Study First Submitted QC: 2025-06-23
• Last Update Submitted: 2025-06-23
• Study Start: 2025-06-24
• Study First Posted: 2025-06-29
• Last Update Posted: 2025-06-29
• Primary Completion: 2026-11-20
• Study Completion: 2027-02-20

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy
• Patients between the ages of 18 and 70
• ASA (American Society of Anesthesiologists) physical status classification II-III

Exclusion Criteria

• Patients with an ejection fraction below 35%
• Patients who did not consent to participate in the study
• Patients undergoing emergency surgery
• Patients who are allergic to the anesthetic drugs used
• Patients who have undergone lung resection
• Those with a history of mechanical ventilation in the 2 months before surgery
• Patients who have undergone total circulatory arrest and deep hypothermia
• Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance
• Morbid obesity (Body Mass Index>35kg/m2)
• Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)
• COPD (FEV1<70%)
• Patients with chronic renal failure (serum creatine>1.8 mg/dl)
• Anemia (Hg<10 gr/dl)
• Patients who have had an intraaortic balloon pump placed.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effects on intraoperative oxygenation, hemodynamics, lung compliance and airway pressures	First one day