Post Infarction Exercise Effects on Myocardial Function Assessed by 2D Strain Ultrasound

Not Applicable

Completed

• Conditions: Myocardial Infarction
• Interventions: Other: Cardiac training program

• Registration Number: NCT02932696
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

The main goal of our project is to study and describe the effect of exercise training on systolic and diastolic myocardial function assessed by 2D ultrasound strain after myocardial infarction.

Our working hypothesis is that the intrinsic myocardial contractility and relaxation assessed by global longitudinal strain in phase II (or 2D strain) during post-infarction exercise training will be improved compared to baseline values as well as compared to values in a no-training group. Should this hypothesis prove true, it would help explain the improvements in functional capacity observed during the post-infarction period and after exercise training.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-10-12
• Study First Submitted QC: 2016-10-12
• Study First Posted: 2016-10-13
• Study Start: 2017-05-05
• Primary Completion: 2019-07-11
• Study Completion: 2019-07-11
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-23
• Last Update Posted: 2019-10-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• The patient must have given his/her informed and signed consent
• The patient must be insured or beneficiary of a health insurance plan
• The patient is available for 4 months of follow-up
• The patient had a first myocardial infarction episode (within the past 3 months) requiring medical treatment or revascularisation (e.g. balloon angioplasty) or aortocoronary bypass

Exclusion Criteria

• The patient is simultaneously participating in (or has participated in the past 3 months) another interventional study
• The patient is in an exclusion period determined by a previous study
• The patient is under judicial protection or under guardianship
• It is impossible to correctly inform the patient or the patient refuses to sign the consent
• The patient is pregnant, parturient, or breastfeeding
• Contra indication for exercise training
• Valve prosthesis
• Severe valvular disease
• Pacemaker
• Heart transplant
• Non sinus rhythm

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise training	Cardiac training program	Patients in this arm were encouraged to participate in an exercise training program, and they accepted to do so. Intervention: Cardiac training program

Primary Outcome Measures

Name	Time	Method
The % global longitudinal strain of the left ventricle	3 months

Secondary Outcome Measures

Name	Time	Method
left ventricle longitudinal systolic strain rate	T0 + 3 months
% radial systolic strain	T0 + 3 months
Radial diastolic strain rate	T0 + 3 months
% circumferential systolic strain	T0 + 3 months
S' wave velocity (cm/s)	T0 + 3 months
maximal oxygen consumption (VO2max; mL/min/kg)	T0 + 3 months
Left ventricle mass (g/m^2)	T0 + 3 months
A' wave velocity (cm/s)	T0 + 3 months
First ventilatory threshold (mL/min/kg)	T0 + 3 months
left ventricle longitudinal diastolic strain rate	T0 + 3 months
% circumferential diastolic strain	T0 + 3 months
Circumferential systolic strain rate	T0 + 3 months
maximum aerobic power (watts)	T0 + 3 months
% radial diastolic strain	T0 + 3 months
Radial systolic strain rate	T0 + 3 months
Circumferential diastolic strain rate	T0 + 3 months
Telediastolic volume (mL)	T0 + 3 months
E' wave velocity (cm/s)	T0 + 3 months
The E/A ratio	T0 + 3 months
Telesystolic volume (mL)	T0 + 3 months
Ejection fraction of the left ventricle	T0 + 3 months

Trial Locations

Locations (1)

CHU de Nîmes - Hôpital Universitaire Carémeau; 🇫🇷 Nîmes Cedex 09, France