Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes
Not Applicable
- Conditions
- Type2 Diabetes
- Interventions
- Registration Number
- NCT04907838
- Lead Sponsor
- University of Southern Denmark
- Brief Summary
This study evaluates the role of endothelin in insulin stimulated vasodilation and glucose uptake. The subjects will complete an hyperinsulinemic euglycemic clamp with and without blockade of the endothelin receptors.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
- Type 2 diabetes OR healthy control (no type 2 diabetes)
- BMI<32
Exclusion Criteria
- heart disease
- pregnancy or birth within 3 month
- smoking
- Kidney disease
- beta-blockers
- insulin treatment (for type 2 diabetics)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Healthy controls BQ123 + BQ788 BQ123 (25 nmol/min), BQ788 (25 nmol/min) Type 2 diabetics BQ123 BQ123 (25 nmol/min), BQ788 (25 nmol/min) Type 2 diabetics BQ123 + BQ788 BQ123 (25 nmol/min), BQ788 (25 nmol/min) Healthy controls Insulin clamp BQ123 (25 nmol/min), BQ788 (25 nmol/min) Type 2 diabetics Insulin clamp BQ123 (25 nmol/min), BQ788 (25 nmol/min) Healthy controls BQ123 BQ123 (25 nmol/min), BQ788 (25 nmol/min)
- Primary Outcome Measures
Name Time Method Glucose infusion rate 3.5 hours Glucose infusion rate required to maintain euglycemia during insulin clamp with and without endothelin blockade
Leg blood flow 3.5 hours Effect of endothelin receptor blockade on leg blood flow (ultrasound Doppler) during insulin clamp with and without endothelin blockade
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cardiovascular and Renal Research
🇩🇰Odense, Denmark