Insulin-induced microvascular activity in patients with essential hypertension: a possible role for angiotensin II AT1-receptor blockers.
- Conditions
- HypertensionHypertensie
- Registration Number
- NL-OMON24297
- Lead Sponsor
- Prof. CDA StehouwerHead Department of Internal MedicineUniversity Hospital MaastrichtP.O. Box 58006202 AZ Maastrichtcsteh@sint.azm.nl
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 32
Inclusion Criteria
Inclusion criteria hypertensive subjects:
1. 18-60 years
Exclusion Criteria
1. Obesity (BMI>27kg/m2)
2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
4. Smoking
5. Alcohol use >4U/day
6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
7. Pregnancy
8. Wearing contact lenses
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method functional recruitment of capillaries in the skin.
- Secondary Outcome Measures
Name Time Method - perfused capillary density in the nailfold.<br>- Endothelium- (in)dependent vasodilatation of finger skin microcirculation<br>- Density of arterioloes, capillaries and venules in the bulbar conjunctiva.<br>- Diameter of arterioles and venules in the bulbar conjunctiva