Role of AT1-receptor Blockers in Insulin-induced Vasodilation.

Not Applicable

• Conditions: Hypertension; Insulin Resistance; Microcirculation
• Interventions: Drug: Irbesartan; Drug: Felodipine; Drug: Placebo

• Registration Number: NCT00742066
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular effects in normotensive control subjects?

Detailed Description

Not available

Study Timeline

• Study Start: 2008-03
• Study First Submitted: 2008-08-26
• Study First Submitted QC: 2008-08-26
• Study First Posted: 2008-08-27
• Primary Completion: 2009-07
• Study Completion: 2009-07
• Status Verified: 2011-03
• Last Update Submitted: 2011-03-16
• Last Update Posted: 2011-03-17

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

hypertensive subjects:

1. 18-60 years
2. Caucasian
3. untreated hypertension >140/90mmHg.

normotensive subjects:

1. 18-60 years
2. Caucasian
3. Blood pressure <140/90 mmHg.

Exclusion Criteria

1. Obesity (BMI>27kg/m2)
2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
4. Smoking
5. Alcohol use >4U/day
6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
7. Pregnancy
8. Wearing contact lenses

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
I	Irbesartan	Irbesartan
II	Felodipine	Felodipine
III	Placebo	Placebo

Primary Outcome Measures

Name	Time	Method
functional recruitment of capillaries in the skin	July 2009

Secondary Outcome Measures

Name	Time	Method
perfused capillary density in the nailfold	July 2009
Endothelium- (in)dependent vasodilatation of finger skin microcirculation	July 2009
Density of arterioles, capillaries and venules in the bulbar conjunctiva.	July 2009
Diameter of arterioles and venules in the bulbar conjunctiva	July 2009

Trial Locations

Locations (1)

University Hospital Maastricht; 🇳🇱 Maastricht, P.O. Box 5800, Netherlands