Insulin-induced microvascular activity in patients with essential hypertension: a possible role for angiotensin II AT1-receptor blockers-Amendement 26-03-2008.
Completed
- Conditions
- high blood pressurehypertension1001842410057166
- Registration Number
- NL-OMON31747
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 38
Inclusion Criteria
Main study:
Inclusion criteria hypertensive subjects: 18-60 years, Caucasian, untreated hypertension>140/90mmHg.
Inclusion criteria normotensive subjects : 18-60 years, Caucasian, blood pressure <140/90 mmHg.;Amendement:
18-60 years, Caucasian, blood pressure <140/90 mmHg.
Exclusion Criteria
Obesity (BMI>27kg/m2), cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure), impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA, smoking, alcohol use >4U/day, use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs), and pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main Study:<br /><br>- functional recruitment of capillaries in the skin.<br /><br><br /><br>Amendement:<br /><br>- the angiotensin II AT1-recptor blockade with a single oral dose of 600mg<br /><br>irbesartan. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Main Study:<br /><br>- perfused capillary density in the nailfold.<br /><br>- Endothelium- (in)dependent vasodilatation of finger skin microcirculation<br /><br>- Density of arterioloes, capillaries and venules in the bulbar conjunctiva.<br /><br>- Diameter of arterioles and venules in the bulbar conjunctiva.<br /><br><br /><br>Amendement:<br /><br>- Time-course of angiotensin II AT1-recptor blockade after 600 mg irbesartan<br /><br>- plasma angiotensin II and active plasma renin concentrations (APRC)<br /><br>- Blood pressure drop after intake irbesartan (600mg) and felodipien ER (20mg)</p><br>