Insulin-induced microvascular dilatation during a physiological stimulus - Studies in hypertension and obesity.

• Conditions: Hypertension - hypertensieObesity - obesitasMicrocirculation - microcirculatie

• Registration Number: NL-OMON20799

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

Inclusion criteria healthy normotensive subjects:

1. 18-60 years

Exclusion Criteria

- Exclusion criteria for healthy normotensive and hypertensive subjects:

1. Obesity (BMI>27kg/m2)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Functional recruitment of capillaries in the skin.

Secondary Outcome Measures

Name	Time	Method
- Perfused capillary density in the nailfold.<br /><br>- Endothelium- (in)dependent vasodilatation of finger skin microcirculation<br /><br>- Density of arterioles, capillaries and venules in the bulbar conjunctiva.<br /><br>- Diameter of arterioles and venules in the bulbar conjunctiva.<br /><br>- Insulin sensitivity (HOMA-IR)