se of mechanical insufflation-exsufflation for ineffective cough in diseases of the peripheral or central nervous system

Not Applicable

Recruiting

• Conditions: G62.80; I63; Cerebral infarction

• Registration Number: DRKS00020981
• Lead Sponsor: Koninklijke Philips N.V.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Existent severe illness from the neurological or neurosurgical spectrum defined as early rehabilitation Barthel Index (ERBI) < 35 points, a cough deficiency and/or retention of secretion, identified by peak cough flow <270l/min. or diagnosed by application of the airway clearance score (ACS) >7 or cough >1 on ACS (Coplin et al. 2000, Windisch et al. 2017, Tanwar et al. 2019)

Exclusion Criteria

Age <18 years, known bullous pulmonary emphysema, presence of pneumothorax during current clinical treatment or instable sternum.
Amyotrophic lateral sclerosis as well as other progressive neuromuscular disorders and paraplegia, continous intracenous sedation, orally intubated patients, expected death on the ICU

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of mechanical ventilation

Secondary Outcome Measures

Name	Time	Method
incidence of ventilator associated pneumonia