The effect of cough assist and inspiratory muscle training in patients with NMD

Not Applicable

• Conditions: Musculoskeletal Diseases; Respiratory; Paediatrics; Neuromuscular diseases

• Registration Number: PACTR201506001171421
• Lead Sponsor: Anri Human

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-06-10
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

MI-E study:

Documented diagnosis of any congenital or paediatric/adolescent NMD.

Patients admitted for acute respiratory infections and/or respiratory complications such as increased work of breathing, respiratory muscle fatigue, orthopnoea, retention of secretions/inability to clear secretions, decreased peak expiratory cough flow.

IMT study:

Documented diagnosis of any congenital or paediatric/adolescent NMD.

Patients admitted for acute respiratory infections and/or respiratory complications such as increased work of breathing, respiratory muscle fatigue, orthopnoea, retention of secretions/inability to clear secretions, decreased peak expiratory cough flow.

Exclusion Criteria

MI-E study:

Unstable vital signs such as resting arterial O2 saturation (SpO2) of <90% and/or end-tidal carbon dioxide tension (PETCO2) of >7kPa on the day of recruitment. If the vital signs should stabilise within the following 48 hours, patients will be reconsidered for inclusion.

If patients are terminally ill, have bullae emphysema, scoliosis > 100 degrees (La Place¿s Law) or cannot cooperate/follow basic instructions.

Previous history of a pneumothorax/ pneumo-mediastinum, recent (< 6months) barotrauma, thoracic/abdominal surgery.

Patient that present with cardiac failure (confirmed by a physician).
Patient that are participating in the IMT study, as this might influence their reaction to MI-E treatment as well as their clinical outcomes.

Patients that are unable to cooperate/comply with the cough assist technique(s).

IMT study:

Patients that are terminally ill.

Patients with <25% predicted value VC will be excluded.

Patients that are unable to cooperate/comply with the training programme.

Study & Design

• Study Type: Interventional
• Study Design: Not specified