NCT02734563已完成不适用
Collagen Alterations in Patients With Abdominal Wall Hernias
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 174
- 试验地点
- 1
- 主要终点
- Type IV and V collagen synthesis and breakdown
研究概览
简要总结
The aim of this study was to evaluate collagen turnover in patients with multiple hernias
详细描述
Venous blood was collected and markers for type IV and V collagen synthesis and breakdown was measured
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •patients with a history of three hernia repairs (multiple hernia group)
- •patients without any history or presence of hernias (control group)
排除标准
- •connective tissue disorder (Ehlers-Danloss/Marfan)
- •presence of hernia upon clinical examination (control group)
结局指标
主要结局
Type IV and V collagen synthesis and breakdown
时间窗: 3 months
Products from type IV and V collagen synthesis and breakdown are measured in serum. with ELISA from Nordic Bioscience A/S, Herlev, Denmark. Specifically, the biomarker for type IV collagen synthesis (P4NP) and breakdown (C4M), and for type V collagen synthesis (P5CP) and breakdown (C5M) was measured. The concentration unit for all parameters is ng/ml.
次要结局
未报告次要终点
研究者
Lars Nannestad Jorgensen
Professor, MD
Bispebjerg Hospital
研究点 (1)
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