Collagen Alterations in Patients With Abdominal Wall Hernias
Completed
- Conditions
- Hernia, Abdominal
- Interventions
- Other: Collagen turnover
- Registration Number
- NCT02734563
- Lead Sponsor
- Bispebjerg Hospital
- Brief Summary
The aim of this study was to evaluate collagen turnover in patients with multiple hernias
- Detailed Description
Venous blood was collected and markers for type IV and V collagen synthesis and breakdown was measured
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 174
Inclusion Criteria
- patients with a history of three hernia repairs (multiple hernia group)
- patients without any history or presence of hernias (control group)
Exclusion Criteria
- connective tissue disorder (Ehlers-Danloss/Marfan)
- presence of hernia upon clinical examination (control group)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Multiple hernia group Collagen turnover Males undergoing at least three repairs of abdominal wall hernias at three different anatomic locations. Collagen turnover is analysed. Control group Collagen turnover Males without any history or presence of hernias
- Primary Outcome Measures
Name Time Method Type IV and V collagen synthesis and breakdown 3 months Products from type IV and V collagen synthesis and breakdown are measured in serum. with ELISA from Nordic Bioscience A/S, Herlev, Denmark. Specifically, the biomarker for type IV collagen synthesis (P4NP) and breakdown (C4M), and for type V collagen synthesis (P5CP) and breakdown (C5M) was measured. The concentration unit for all parameters is ng/ml.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Bispebjerg Hospital
🇩🇰Copenhagen, NV, Denmark