Comparison of Acetate Ringer's Solution Versus Ringer's Lactated Solution for Fluid Resuscitation in Patients with Acute Pancreatitis
- Conditions
- Outpatient who presents with acute pancreatitis.Outpatient,acute pancreatitis.
- Registration Number
- TCTR20170903001
- Lead Sponsor
- Gastroenterological association of Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 50
Patients aged 18-80 years who were admit with diagnosis of acute pancreatitis.
Diagnosis was comfirmed by the presence of 2 or more of the of
the following criteria
1) Epigastric abdominal pain.
2) Elevation in serum amylase and/or lipase level greater than
3 times the upper limit of normal.
3) Confirmatory findings on cross-sectional imaging.
Known history of severe cardiovascular, respiratory, renal, hepatic, hematologic or immunologic disease.
defined as
1. Aged 80 years or older.
2. Greater than New York Heart Association class II heart failure.
3. Active myocardial ischemia.
4. Cardiovascular intervention within previous 60 days.
5. History of cirrhosis.
6. Chronic kidney disease with creatinine clearance < 40 ml/min.
7. Chronic obstructive pulmonary disease with requirement for
home oxygen.
8. Patients with a history of metastasis malignancy.
9. Patients with a history of autoimmune disease include autoimmune
pancreatitis..
10. Chronic infectious disease including HIV and tuberculosis.
11. Patients with infection including cholescystitis and cholangitis.
12. Patients with bowel ischemia and bowel perforation.
13. Patients with hypercalcemia.
14. Sepsis (presence of suspected or confirmed infection in setting of SIRS)
15. Rhabdomyolysis.
16. Post-intervention pancreatitis.
17. Severe pancreatitis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SIRs (systemic inflamatory response) ratio at 48 hours after treatment 48 hours Comparison SIRs reduction at 48 hours after treatment in acute pancreatitis patient between Lactated
- Secondary Outcome Measures
Name Time Method Response of inflammatory marker in acute pancreatitis patient. 48 hours Comparison inflamatory marker reduction ratio after treatment both groups