Evaluation of Corneal Endothelial Changes After Uneventful Phacoemulsification in Diabetic and Non-diabetic Patients in Relation to the Level of Glcosylated Hemoglobin Level

Not Applicable

• Conditions: Corneal Endothelial Changes After Phacoemulsification
• Interventions: Device: Specular biomicroscopy

• Registration Number: NCT05426590
• Lead Sponsor: Marwa Ahmed

Brief Summary

Evaluation of corneal endothelial changes after uneventful phacoemulsification in diabetic and non-diabetic patients using specular biomicroscopy in relation to the level of glcosylated hemoglobin level

Detailed Description

86 patients will be divided into two equal groups of diabetic and non-diabetic patients will undergo phacoemulsification of cataract will be evaluated thier endocelium before surgery and 3 weeks after surgery to detect the effect of level of glcosylated hemoglobin on the endothelial changes after uneventful phacoemulsification

Study Timeline

• Study Start: 2022-05-20
• Status Verified: 2022-06
• Study First Submitted: 2022-06-04
• Study First Submitted QC: 2022-06-21
• Last Update Submitted: 2022-06-21
• Study First Posted: 2022-06-22
• Last Update Posted: 2022-06-22
• Primary Completion: 2022-11-17
• Study Completion: 2022-11-17

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

• Diabetics and non-diabetic patients undergo cataract surgery
• Age between 50-60 years old
• Corrected distance visual acuity<0.4
• Gender: both genders.

Exclusion Criteria

• Chronic Ocular diseases (glaucoma,uveitis, amblyopia, strabismus,keratoconus, corneal opacity).
• corneal dystrophy History of previous keratitis or viral corneal infection. Corneal dystrophy Ocular trauma. Previous ocular surgery. Complicated cataract surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Diabetic patient	Specular biomicroscopy	Patient with diabetes will undergo cataract surgery
Non diabetic patients	Specular biomicroscopy	Healthy non diabetic patients will undergo cataract surgery

Primary Outcome Measures

Name	Time	Method
Defferentiate patients into diabetic and non-diabetic patients according to the endothelial changes after uneventful phacoemulsification	6 monthes	Detect effect of glycosylated hemoglobin level after uneventful phacoemulsification in diabetic and non-diabetic patients

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Egypt