Corneal Endothelial Cell Loss in Diabetes Type II During Cataract Surgery
- Conditions
- Diabetes Mellitus
- Registration Number
- NCT00446277
- Lead Sponsor
- Frederiksberg University Hospital
- Brief Summary
The aim of the present study is to evaluate changes in the morphology and function of the corneal endothelium before and after cataract surgery in patients with diabetes type II. Also to explain if determination of HgbA1c in diabetics is a predictor for the changes in morphology and function.
- Detailed Description
Thirty patients with Diabetes type II and thirty non-diabetes patients scheduled to cataract surgery (phacoemulsification with intraocular lens implantation) were invited to participate in the study. Preoperatively, all patients had a full eye examination and 3 endothelial cell photos were taken.
Three months postoperatively the patients were called for a re-examination including 3 endothelial cell photos. The function of the cornea is dependent of the number and morphology of the endothelial cells, and even small traumas like cataract surgery may disrupt the cornea integrity leading to corneal haze and blur. Diabetics may be more vulnerable to corneal stress.
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 30
- Patients with cataract scheduled for surgery
- Patients with corneal diseases, glaucoma or uveitis, previous intraocular surgery or eye traumas.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method variation in cell size corneal endothelial cell count (cells / mm2) percentage of hexagonal cells central corneal thickness
- Secondary Outcome Measures
Name Time Method intraocular pressure visual acuity
Trial Locations
- Locations (1)
Department of Ophthalmology, Frederiksberg University Hospital
🇩🇰Frederiksberg, Copenhagen, Denmark