Perception of reflux and mucosal integrity in the proximal oesophagus

Completed

• Conditions: GORD; Reflux disease; 10017977

• Registration Number: NL-OMON38752
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 11

Inclusion Criteria

• Patients with heartburn lasting more than 12 months
• A 24-hour pH-measurement showing a symptom association probability > 95%
• Written informed consent
• Age 18 - 75 years

Exclusion Criteria

• Barrett*s oesophagus
• History of GI cancer
• GI tract surgery (except appendectomy)
• Inability to stop PPI, H2-receptor antagonist or prokinetic drug for 10 days

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Oesophageal sensitivity represented by the perfusion sensitivity score</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Transepithelial permeability to small molecules<br /><br>• Transepithelial resistance of oesophageal mucosa<br /><br>• Extracellular impedance measured in vivo with ETIS</p><br>