Reflux characteristics in patients with suspected laryngopharyngeal reflux; a prospective study using ambulatory pH/impedance measurements
- Conditions
- throat irritation due to stomach acid10017977
- Registration Number
- NL-OMON34249
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Written informed consent
Minimum age: 18 years
20 LPR suspected patients: reflux finding score of >7 and RSI questionnaire >13
10 healthy volunteers
Exclusion Criteria
Surgery of the GI tract other than appendectomy or cholecystectomy
Inability to stop the use of medication influencing GI motility for one week
Inability to stop the use of proton pump inhibitors for one week
Infectious and allergic causes of laryngitis
Patients with aerodigestive malignancies and/or radiation therapy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Total number of mixed reflux that reach the proximal esophagus</p><br>
- Secondary Outcome Measures
Name Time Method <p>Laryngoscopic evidence after 3 months of PPI therapy<br /><br>RSI questionnaires after 3 months of PPI therapy</p><br>