ovel diagnostic approaches for the diagnosis of Alzheimer's Disease: Technology assessment and clinical effectiveness.

Completed

Conditions: Dementia
Neurodegenerative disorders
10042258
Alzheimer's disease

Registration Number: NL-OMON36838

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 251

Inclusion Criteria

- All new consecutive patients of the participating memory clinics who are suspected of having a primary neurodegenerative disease. This means all patients with subjective and/or objective memory complaints.
- CDR 0, 0.5 or 1
- Mini Mental State Examinations (MMSE) score must be 20 or higher.
- Availability of a reliable informer or proxy (who visits or contacts the patient at least once a week).

Exclusion Criteria

- Normal Pressure Hydrocephalus (NPH)
- Huntington's disease
- Recent Transient Ischaemic Attack (TIA) (<2 years) or Cerebral Vascular Accident (CVA) or TIA/CVA followed by cognitive impairment (within 3 months)
- History of Schizophrenia, other psychotic disorders (< 12 months)
- Major depression (< 12 months)
- Alcohol abuse
- Brain-tumor, epilepsy, encephalitis
- Absence of a reliable informant
- Probably not available for follow-up

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Biomarkers in liquor<br /><br>- Magnetic Resonance Imaging (MRI)<br /><br><br /><br>Disease severity:<br /><br>- MMSE<br /><br>- CDR<br /><br><br /><br>Quality of life:<br /><br>- Euro-Qol-5D (patient and caregiver)<br /><br>- QoL-AD (patient and caregiver)<br /><br><br /><br>Costs:<br /><br>- RUD-Lite<br /><br>- ProDisq<br /><br>- Other resource use<br /><br>- Health and labour questionnaire</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Demografic and administrative data<br /><br>- General clinical data<br /><br><br /><br>Patient questionnaires:<br /><br>- NPI<br /><br>- DAD<br /><br>- GDS-15<br /><br><br /><br>Neuropsychological tests<br /><br><br /><br>Caregiver burden:<br /><br>- SoCQ<br /><br>- CareQol</p><br>