Adding Dexmedetomidine to Mannitol to Attenuate the Increase of Intracranial Pressure

Not Applicable

Recruiting

• Conditions: Dexmedetomidine
• Interventions: Drug: Dexmedetomidine with Mannitol; Drug: Mannitol (20%)

• Registration Number: NCT07064720
• Lead Sponsor: Cairo University

Brief Summary

Dexmedetomidine is a potent alpha-2 adrenergic receptor agonist. In addition, dexmedetomidine-induced stimulation of the postsynaptic alpha-2 adrenergic receptor on the cerebral blood vessels can cause cerebral vasoconstriction and decrease cerebral blood flow

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-12
• Status Verified: 2024-07
• Study First Submitted: 2025-07-06
• Study First Submitted QC: 2025-07-06
• Last Update Submitted: 2025-07-06
• Study First Posted: 2025-07-15
• Last Update Posted: 2025-07-15
• Primary Completion: 2025-12-15
• Study Completion: 2026-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA I-II Patients scheduled for elective robot-assisted laparoscopic prostatectomy

Exclusion Criteria

• • ASA physical status > II

  • Cardiac patients
  • Cerebrovascular disease
  • Glaucoma
  • Hepatic failure
  • Renal failure
  • History of anaphylactic reaction to dexmedetomidine or mannitol
  • Hemodynamic instability
  • Cannot measure ONSD for example due to ophthalmological problems.
  • Any cause of preoperative increase in ICP for example intracranial space occupying lesions.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group (D)	Dexmedetomidine with Mannitol	Dexmedetomidine with Mannitol
Group (M)	Mannitol (20%)	Mannitol only

Primary Outcome Measures

Name	Time	Method
optic nerve sheath diameter	90 minutes

Secondary Outcome Measures

Name	Time	Method
Postoperative cardiac complications	24 hours
Postoperative neurologic complications	24 HOURS
Duration of hospital stay	30 days

Trial Locations

Locations (1)

facility of medicine Cairo university; 🇪🇬 Cairo, Egypt