临床试验/NCT07064720

NCT07064720已完成2 期

Adding Dexmedetomidine to Mannitol to Attenuate the Increase of Intracranial Pressure

Cairo University1 个研究点分布在 1 个国家目标入组 60 人开始时间: 2024年7月12日最近更新: 2026年1月21日

干预措施

试验速览

阶段: 2 期
状态: 已完成
发起方: Cairo University
入组人数: 60
试验地点: 1
主要终点: optic nerve sheath diameter

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Dexmedetomidine is a potent alpha-2 adrenergic receptor agonist. In addition, dexmedetomidine-induced stimulation of the postsynaptic alpha-2 adrenergic receptor on the cerebral blood vessels can cause cerebral vasoconstriction and decrease cerebral blood flow

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围: 40 Years 至 70 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•ASA I-II Patients scheduled for elective robot-assisted laparoscopic prostatectomy

排除标准

•• ASA physical status > II
•Cardiac patients
•Cerebrovascular disease
•Hepatic failure
•Renal failure
•History of anaphylactic reaction to dexmedetomidine or mannitol
•Hemodynamic instability
•Cannot measure ONSD for example due to ophthalmological problems.
•Any cause of preoperative increase in ICP for example intracranial space occupying lesions.

研究组 & 干预措施

Group (D)

Experimental

Dexmedetomidine with Mannitol

干预措施: Dexmedetomidine with Mannitol (Drug)

Group (M)

Experimental

Mannitol only

干预措施: Mannitol (20%) (Drug)

结局指标

主要结局

optic nerve sheath diameter

时间窗: 90 minutes

次要结局

Postoperative cardiac complications(24 hours)
Postoperative neurologic complications(24 HOURS)
Duration of hospital stay(30 days)

研究者

发起方

Cairo University

申办方类型

Other

责任方

Principal Investigator

主要研究者

Amr Samir Wahdan

Assistant Professor of anesthesia, SICU & and pain management

Cairo University

研究点 (1)

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