Intravenous metoclopramide versus intravenous promethazine for hyperemesis gravidarum: a double-blind, randomised trial

Completed

• Conditions: Hyperemesis gravidarum; Pregnancy and Childbirth; Excessive vomiting in pregnancy

• Registration Number: ISRCTN34918844
• Lead Sponsor: niversity of Malaya (Malaysia)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-07-31
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 128

Inclusion Criteria

1. Pregnant women, age limit >17 to 50 years
2. Gestation <16 weeks
3. First hospitalisation for hyperemesis gravidarum in current pregnancy
4. Clinical dehydration with ketonuria on urine dipstick

Exclusion Criteria

1. Multiple gestation
2. Established non viable pregnancy
3. Allergy to metoclopramide or promethazine
4. Pre-exiting medical condition which can cause nausea and vomiting if known, for example:
4.1. Concomitant confounders of severity of nausea and vomiting e.g. culture proven symptomatic urinary tract infection, dengue fever
4.2. Gastrointestinal causes of vomiting e.g. gastro-enteritis
4.3. Medical causes of vomiting e.g. diabetic ketoacidosis

Study & Design

• Study Type: Interventional
• Study Design: Not specified