Blood Transfusions in Thalassemia Patients, Complications and Adverse Effects

Completed

• Conditions: Thalassemia; Sickle Cell Anemia
• Interventions: Other: Clinical medical record summary

• Registration Number: NCT00971880
• Lead Sponsor: HaEmek Medical Center, Israel

Brief Summary

Patients suffering from Thalassemia or another hemoglobinopathies required regular blood transfusions. The complications and adverse effects of blood transfusions can be classified as immediate and late. Among the immediate effects the most common are allergic reactions and fever, besides congestive heart failure in patients with cardiomyopathy. The late effects are mostly related to blood transmitted infections like HIV or Hepatitis C infections.

The purpose of this study is to summarize the data of those complications in a cohort of 100 patients receiving regular blood transfusion.

Detailed Description

About 100 patients aged several months to 50 years are treated in the Pediatric Hematology Unit, most of those patients receive blood transfusions monthly. The adverse reactions were routinely recorded during each transfusion. All the patients were also screened annually for the incidence of blood transmitted infections principally HIV and Hepatitis C. All those records will be systematically screened and all the immediate or late adverse reactions and complications related to blood transfusions will be summarized.

A second goal of this study will be to control the staff strictness related to the ministry of health protocol dealing to blood transfusions.

Study Timeline

• Study Start: 2009-05
• Study First Submitted: 2009-09-03
• Study First Submitted QC: 2009-09-03
• Study First Posted: 2009-09-04
• Primary Completion: 2010-11
• Study Completion: 2010-11
• Status Verified: 2011-08
• Last Update Submitted: 2011-08-25
• Last Update Posted: 2011-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients receiving blood transfusions due to chronic hematologic disorders

Exclusion Criteria

• Not applicable

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients receiving blood transfusions	Clinical medical record summary	All the patients with blood disorders that require blood transfusions

Trial Locations

Locations (1)

Pediatric Hematology Unit and Pediatric Dpt B - HaEmek Medical Center; 🇮🇱 Afula, Israel