A pilot study of efficacy and safety of microneedling-assisted topical botulinum toxin A for the treatment of enlarged facial pores: a split-face randomized-controlled pilot study
- Conditions
- Enlarged facial poresBotulinum toxinEnlarged poresMicroneedle
Recruitment & Eligibility
- Status
- nknown
- Sex
- All
- Target Recruitment
- 25
1. Thai descendants
2. There are enlarged pores on both cheeks. By definition, enlarged pores must be visible to the naked eye (visible topographic enlarged facial pores) at a distance of 30 cm and examined by two dermatologists with a consensus.
1. Pregnant, breastfeeding, or after giving birth for no more than three months or plan to become pregnant during six months.
2. Using vitamin A compounds or chemical peeling agents or injecting botulinum toxin on the cheek area in the last six months
3. History of allergy to anesthetics or botulinum toxin
4. History of hypertrophic scars or keloids
5. Open wounds, infected skin, or skin rashes on the face
6. Having underlying diseases such as diabetes, collagen-related disorders, immunodeficiencies, or having an underlying condition that the researcher considers to be unsafe if participating in the program, such as epilepsy
7. History of regularly using steroids or smoking.
8. History of using anticoagulants, antiplatelet agents, or ginkgo leaf extract.
9. Volunteers with an implanted pacemaker with an implanted metallic device.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pore volume before treatment, 2 weeks, 1 month, 3 months, 6 months after treatment Antera 3D analysis
- Secondary Outcome Measures
Name Time Method Adverse events 1 week, 2 weeks, 1 month, 3 months, 6 months after treatment Clinical evaluation,Sebum production 2 weeks, 1 month, 3 months, 6 months after treatment Sebumeter