Correction of acidosis in hemodialysis patients. Effects on protein metabolism, investigated by tracer technique and messenger-ribonucleic acid determination for ubuquitin and proteasome subunits.
Completed
- Conditions
- End-stage renal failureNutritional, Metabolic, EndocrineRenal failure
- Registration Number
- ISRCTN27844532
- Lead Sponsor
- Karolinska University Hospital (Sweden)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
1. Clinically stable hemodialysis patients
2. >18 Years of age
Exclusion Criteria
1. Clinically obvious malnutrition
2. Ongoing infection
3. Diabetes mellitus
4. Untreated congestive heart failure
5. Treatment with corticosteroids or other immunosuppressive agents
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Muscle protein turnover
- Secondary Outcome Measures
Name Time Method 1. messenger-Ribonucleic Acid (mRNA) for ubuquitin and proteasome subunits<br>2. Plasma and muscle intracellular amino acid concentrations<br>3. Serum albumin