NL-OMON45074已完成不适用
The effect of correction of metabolic acidosis in chronic kidney disease on intrarenal RAS activity. - BIC study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- male or female adult (>18 years)
- •- chronic kidney disease stage 4, i.e. eGFR (MDRD) 15-30 ml/min
- •- plasma bicarbonate concentration of <24 and >15 meq/L, the latter because in that case it seems highly recommended to start sodiumbicarbonate suppletion and not to postpone this
排除标准
- •- plasma bicarbonate level >24 meq/L or <15 meq/L
- •- sodiumbicarbonate use in the 6 months preceeding the study
- •- a kidney transplant in situ
- •- heart failure
- •- liver cirrhosis
- •- blood pressure > 140/90 mmHg despite the use of 3 different antihypertensives
- •- a history of inadherence to medication
- •- use of calcineurin inhibitors (these immunosuppressive drugs are known to induce metabolic acidosis and influence electrolytes and acid-base balance)
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