NL-OMON45074
Completed
Not Applicable
The effect of correction of metabolic acidosis in chronic kidney disease on intrarenal RAS activity. - BIC study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- chronic kidney disease
- Sponsor
- Erasmus MC, Universitair Medisch Centrum Rotterdam
- Enrollment
- 48
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- male or female adult (\>18 years)
- •\- chronic kidney disease stage 4, i.e. eGFR (MDRD) 15\-30 ml/min
- •\- plasma bicarbonate concentration of \<24 and \>15 meq/L, the latter because in that case it seems highly recommended to start sodiumbicarbonate suppletion and not to postpone this
Exclusion Criteria
- •\- plasma bicarbonate level \>24 meq/L or \<15 meq/L
- •\- sodiumbicarbonate use in the 6 months preceeding the study
- •\- a kidney transplant in situ
- •\- heart failure
- •\- liver cirrhosis
- •\- blood pressure \> 140/90 mmHg despite the use of 3 different antihypertensives
- •\- a history of inadherence to medication
- •\- use of calcineurin inhibitors (these immunosuppressive drugs are known to induce metabolic acidosis and influence electrolytes and acid\-base balance)
Outcomes
Primary Outcomes
Not specified
Similar Trials
Active, not recruiting
Not Applicable
Does correction of acidity decrease kidney damage?EUCTR2013-002037-38-NL
Completed
Not Applicable
Effect of sodium bicarbonate supplementation on nutritional status in patients with kidney diseaseHealth Condition 1: N189- Chronic kidney disease, unspecifiedCTRI/2015/09/006161JIPMER188
Completed
Not Applicable
Correction of metabolic acidosis in continuous ambulatory peritoneal dialysis patients with borderline dialysis adequacy - effect on nutritional status, systemic inflammatory response and patient morbidityISRCTN35726272Hong Kong Health Services Research Fund (Hong Kong)60
Not yet recruiting
Not Applicable
Effect of correction of metabolic acidosis on respiration and hemodynamics in acute respiratory distress syndrome (ARDS) patients during mechanical ventilation: A randomized comparison of sodium bicarbonate and Tris-hydroxymethyl aminomethane (THAM).acute respiratory distress syndrome (ARDS)JPRN-UMIN000021756Osaka University Hospital100
Completed
Not Applicable
High versus standard alkali supplementation in kidney diseaseCTRI/2020/08/027100Jawaharlal Institute of postgraduate Medical Education Research128